Találati lista | Tudóstér

001-es BibID:	BIBFORM049412
Első szerző:	Almássy János (élettanász, biológus, angol-magyar szakfordító)
Cím:	Miocardial infarct induced changes of skeletal type SR calcium channel (RyR1) / J. Almássy, G. Vassort, I. Jóna
Dátum:	2006
Megjegyzések:	In heart failure (HF) skeletal muscle weakness and fatigue develop that could be explained by decreased Ca2+ content of the sarcoplasmic reticulum (SR) concomitant reduction of calcium transients' amplitude, indicating the impaired balance of calcium transport mechanisms. The aim of the present study was to identify putative functional RyR1 changes contributing to the reduced Ca2+ content of the SR.Single RyR1 Ca2+-release channels from rats with HF were reconstituted into planar lipid bilayer and gating behaviour of incorporated channels was studied under voltage-clamp conditions. 1/3 of these channels showed 40% higher conductance compared to RyRs from control rats and the voltage dependency of channel conductance altered, showing still ohmic but polarity dependent conductance characterized by 785 ? 28 pS for positive and 575 ? 31 pS for negative polarity. Altered Ca2+-dependency of channel activity was also observed on RyRs from HFafflicted rats, such as enhanced calcium activation and reduced calcium inhibition.
Tárgyszavak:	Természettudományok Biológiai tudományok idézhető absztrakt calcium release
Megjelenés:	Journal of Muscle Research and Cell Motility. - 27 (2006), p. 521. -
További szerzők:	Vassort, Guy Jóna István (1948-) (élettanász, fizikus)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: