Találati lista | Tudóstér

001-es BibID:	BIBFORM049710
Első szerző:	Brancati, Serena B.
Cím:	Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats / Serena B. Brancatia, Zoltán S. Zádori, József Németh, Klára Gyires
Dátum:	2013
ISSN:	0361-9230
Megjegyzések:	The aim of the present study was to analyze the potential role of substance P (SP) in gastric mucosaldefense and to clarify the receptors and mechanisms that may be involved in it. Gastric ulceration wasinduced by oral administration of acidified ethanol in male Wistar rats. Mucosal levels of calcitoningene-related peptide (CGRP) and somatostatin were determined by radioimmunoassay. For analysis ofgastric motor activity the rubber balloon method was used. We found that central (intracerebroventricular)injection of SP (9.3?74 pmol) dose-dependently inhibited the formation of ethanol-induced ulcers,while intravenously injected SP (0.37?7.4 nmol/kg) had no effect. The mucosal protective effect of SPwas inhibited by pretreatment with neurokinin 1-, neurokinin 2-, neurokinin 3- and -opioid receptorantagonists, while - and -opioid receptor antagonists had no effect. Endomorphin-2 antiserumalso antagonized the SP-induced mucosal protection. In the gastroprotective dose range SP failed toinfluence the gastric motor activity. Inhibition of muscarinic cholinergic receptors, or the synthesis ofnitric oxide or prostaglandins significantly reduced the effect of SP. In addition, centrally injected SPreversed the ethanol-induced reduction of gastric mucosal CGRP content. It can be concluded, that SPmay induce gastric mucosal protection initiated centrally. Its protective effect is likely to be mediated byendomorphin-2, and vagal nerve may convey the centrally initiated protection to the periphery, whereboth prostaglandins, nitric oxide and CGRP are involved in mediating this effect.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Calcitonin gene-related peptide Endomorphin Gastric ulcer Substance P Tachykinins
Megjelenés:	Brain Research Bulletin. - 91 (2013), p. 38-45. -
További szerzők:	Zádori Zoltán S. (Farmakológia, gasztrointesztinális farmakológia) Németh József (1954-) (vegyész, analitikus) Gyires Klára
Pályázati támogatás:	75965 OTKA TÁMOP-4.2.1/B-09/1/KMR-2010 TÁMOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: