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001-es BibID:	BIBFORM050126
035-os BibID:	Article ID: e87844
Első szerző:	Fagyas Miklós (orvos)
Cím:	New perspectives in the renin-angiotensin-aldosterone system (RAAS) III : endogenous inhibition of angiotensin converting enzyme (ACE) provides protection against cardiovascular diseases / Miklós Fagyas, Katalin Úri, Ivetta M. Siket, Andrea Daragó, Judit Boczán, Emese Bányai, István Édes, Zoltán Papp, Attila Tóth
Dátum:	2014
ISSN:	1932-6203
Megjegyzések:	ACE inhibitor drugs decrease mortality by up to one-fifth in cardiovascular patients. Surprisingly, there are reports dating back to 1979 suggesting the existence of endogenous ACE inhibitors. Here we investigated the clinical significance of this potential endogenous ACE inhibition. ACE concentration and activity was measured in patient's serum samples (n=151). ACE concentration was found to be in a wide range (47-288 ng/mL). ACE activity decreased with the increasing concentration of the serum albumin (HSA): ACE activity was 56?1 U/L in the presence of 2.4?0.3 mg/mL HSA, compared to 39?1 U/L in the presence of 12?1 mg/mL HSA (values are mean?SEM). Effects of the differences in ACE concentration were suppressed in human sera: patients with ACE DD genotype exhibited a 64% higher serum ACE concentration (range, 74-288 ng/mL, median, 155.2 ng/mL, n=52) compared to patients with II genotype (range, 47-194 ng/mL, median, 94.5 ng/mL, n=28) while the difference in ACE activities was only 32% (range, 27.3-59.8 U/L, median, 43.11 U/L, and range 15.6-55.4 U/L, median, 32.74 U/L, respectively) in the presence of 12?1 mg/mL HSA. No correlations were found between serum ACE concentration (or genotype) and cardiovascular diseases, in accordance with the proposed suppressed physiological ACE activities by HSA (concentration in the sera of these patients: 48.5?0.5 mg/mL) or other endogenous inhibitors. Main implications are that (1) physiological ACE activity can be stabilized at a low level by endogenous ACE inhibitors, such as HSA; (2) angiotensin II elimination may have a significant role in angiotensin II related pathologies.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban ACE HSA endogenous ACE inhibition angiotensin-converting enzyme Molekuláris Medicina
Megjelenés:	Plos One. - 9 : 4 (2014), p. 1-29. -
További szerzők:	Úri Katalin Mányiné Siket Ivetta (1962-) (laborasszisztens) Daragó Andrea (1972-) (orvos, kardiológus) Boczán Judit (1972-) (neurológus) Bányai Emese (1984-) (orvos) Édes István (1952-) (kardiológus) Papp Zoltán (1965-) (kardiológus, élettanász) Tóth Attila (1971-) (biológus)
Pályázati támogatás:	OTKA-K84300 OTKA TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Vaszkuláris tranziens receptor potenciál (TRP) csatornák TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP Kardiológia Kutatócsoport
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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