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001-es BibID:	BIBFORM051034
Első szerző:	Vad Szilvia (nőgyógyász)
Cím:	Sensitivity to activated protein C as a measure of women's reproductive health / Vad S., Póka R., Ajzner É.
Dátum:	2002
Megjegyzések:	Introduction: Evaluation of screening for resistance to activated protein C in estimating the risk of thromboembolism during oral contraceptive use, infertility and miscarriage in a general population of women.Patients and methods: Activated protein C (APC) resistance assay was performed in 3140 women with commercially available functional test kits. Personal and family history thromboembolic disease and occurrence of miscarriage and infertility were compared between patient with sensitivity of APC below and above mean -1SD. The thromboembolic risk calculation was stratified to past and current oral contraceptive users. Results: The mean activated protein C sensitivity rate (APCSR) was 2.368 (min.=1.07, max=3.98, SD=0.438. Oral contraceptive users had a significantly lower APCSR than non-users (2.173 vs.2.33 p<0.05). 10.91% (317 cases) of the total study population had an APCSR below the mean -1 SD (<1.93, APC- resistants). The risk of miscarriage was 2.72 times higher among APC- resistants than among sensitives (95% CI 1.61-4.60). APC resistant cases had a relative risk of 4.04 (95% CI1.79-9.14) to experience difficulty to conceiving. Thromboembolism occurred 2.54 times more frequently (95% CI 1.85-3.48) in the family of APC resistant cases than in those sensitives, and 3.72 times more frequently (95%CI 1.86-7.41) among APC resistant cases themselves than among sensitives. The relative risk of thromboembolism among APC resistant past oral contraceptive users was 2.51 (95% CI 1.06-5.95), while that among current users was 25.8 (95% CI 3.14-221.6).Conclusion: Screening to resistance of activated protein C in general population with high allelic frequency of the Leiden- mutation may help to select women at risk of reduced reproductive health. Correct patient information regarding thromboembolic risk may help to improve safety of oral contraceptive use.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt activated protein C reproductive health
Megjelenés:	Ceska Gynekologia. - 67 : Suppl. 2 (2002), p. 34. -
További szerzők:	Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Ajzner Éva (1968-) (laboratóriumi szakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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