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001-es BibID:	BIBFORM051567
035-os BibID:	PMID:10769717
Első szerző:	Kiss István (Pécs)
Cím:	Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-transferase M1 enzymes / István Kiss, János Sándor, Gábor Pajkos, Barna Bogner, Géza Hegedűs, István Ember
Dátum:	2000
Megjegyzések:	Chemical carcinogens generally require metabolic activation in order to be able to bind to DNA and contribute to cancer causation. Most of the human metabolizing enzymes are genetically polymorphic, and these polymorphisms may affect the enzyme activity or inducibility. In our present study we investigated the connection between genetic polymorphism of cytochrome P450 1A1, 2E1 (phase I enzymes) and glutathione-S-transferase M1 (a phase II enzyme) and colorectal cancer occurrence in a Hungarian population. The CYP 2E1 c2 allele proved to be in significant association with colorectal cancer (OR: 1.91, 95% CI: 1.05-3.52), the CYP 1A1 Val allele was also overrepresented among colon cancer patients (OR: 1.57, 95% CI: 0.90-2.74), and the frequency of GSTM1 homozygous 0 genotype showed only minor difference (OR: 1.19, 95% CI: 0.75-1.35). Combined analysis of the polymorphisms showed that individuals carrying all the three "high-risk" alleles have a strikingly increased risk for sporadic colorectal cancer (OR: 4.62, 95% CI: 1.23-25.68).
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban metabolizing enzymes CYP 1Al CYP 2E1 GSTM l genetic polymorphisrn cancer susceptibility
Megjelenés:	Anticancer Research. - 20 : 1B (2000), p. 519-522. -
További szerzők:	Sándor János (1966-) (orvos-epidemiológus) Pajkos Gábor Bogner Barna Hegedűs Géza Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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