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001-es BibID:	BIBFORM055597
Első szerző:	Erdődi Balázs (szülész-nőgyógyász szakorvosjelölt)
Cím:	Does HE4 improve the diagnosis of pelvic masses in non-experienced examiners? / B. Erdődi, Z. Krasznai, L. Ördög, E. Maka, H. Balla, Z. Tóth, A. Jakab
Dátum:	2014
ISSN:	0960-7692
Megjegyzések:	Objectives: To determine the additive diagnostic value of HE4 tumor marker to in the IOTA's three step strategy for managing adnexal masses focusing on non-experienced examiners.Methods: Imaging properties of ovarian masses were evaluated preoperatively using the IOTA terms and definitions. Two groups of patients were made:1: premenopausal (PEM); 2: postmenopausal (POM). In both groups adnexal masses were characterised by the ♭easy descriptors' and in cases where these were not applicable the IOTA Simple rules had been used. US results then were matched with the preoperative CA125 and HE4 tumor marker levels and histological findings. Results: Overall285patientswithovarianmasseswererecruitedin the analysis (average: 42.0 yrs; range: 12?82 yrs). In the PEM group we had 199 cases (69.82%; range: 12?53 yrs; average: 33.12 yrs),in the POM group 86 cases were involved (30.18%; range: 48?82 yrs; average: 63.09 yrs). In the PEM group 104 patients had the diagnosis based on easy descriptors (52.26%) while 76 patient of the rest fulfilled the requirements for the simple rules. In the POM group 48 patients (55.81%) were diagnosed by the easy descriptors and 36 (41.86%) of the rest could also be scanned according to the M- and B-rules and only 2 (2.33%) patients called for pattern recognition. If CA125 determination was changed to HE4 evaluation in case of easy descriptors the total diagnostic accuracy increased in the PEM group (PPV: 1.00; NPV: 0.98; sensitivity: 33.33%; specificity 100%), similar increase in POM group was not detected. 23 malignant cases were found in the PEM group, 2 of them were diagnosed by easy descriptors while 16 of them were diagnosed by the simple rules. In the POM group 47 malignancies were detected, 32 of them were diagnosed by the easy descriptors additional 12 by M-rules. Conclusions: IOTA easy descriptors and simple rules can be used effectively for non-experienced examiners in more than 90% of the cases. This can be increased by HE4 evaluation especially in premenopausal patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt gynecology ultrasound ovarian mass IOTA
Megjelenés:	Ultrasound in Obstetrics & Gynecology. - 44 : S1 (2014), p. 5. -
További szerzők:	Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Ördög Lilla Maka Eszter (1988-) (szülész-nőgyógyász rezidens) Balla Heidi Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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