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001-es BibID:	BIBFORM056542
Első szerző:	Korponay-Szabó Ilma (gyermekgyógyász)
Cím:	Autoantibodies and CD : past and future of celiac antibody testing / Ilma R. Korponay-Szabó
Dátum:	2014
ISSN:	0277-2116
Megjegyzések:	Celiac disease (CD) is triggered by the consumption of gluten-containing cereals to which patients mount a T-lymphocyte and antibody response in both immunoglobulin A and immunoglobulin G classes coupled with autoantibody production against self-proteins, predominantly type-2 (tissue) transglutaminase (TG2). TG2 autoantibodies are biologically active and bind to their target protein in the patients' tissues, including the gut and extraintestinal tissues. This peculiar systemic anti-TG2 reaction is dependent on the presence of dietary gluten and stops after its elimination. As both anti-TG2 and anti-gliadin antibodies are activity markers, their detection is valuable for the disease recognition and therapy monitoring. High concentrations of serum anti-TG2 antibody positivity supported by highly specific positivity for endomysial antibodies became the critical component of celiac JPGN Volume 59, Supplement 1, July 2014 Celiac Disease: Past, Present, Future Challenges www.jpgn.org S11
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Pediatric Gastroenterology And Nutrition 59 : Suppl. 1 (2014), p. S11-S13. -
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