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001-es BibID:	BIBFORM057407
Első szerző:	Kistamás Kornél (biológus)
Cím:	Oxidative shift in tissue redox potential increases beat-to-beat variability of action potential duration / Kornél Kistamás, Bence Hegyi, Krisztina Váczi, Balázs Horváth, Tamás Bányász, János Magyar, Norbert Szentandrássy, Péter P. Nánási
Dátum:	2015
ISSN:	0008-4212
Megjegyzések:	Profound changes of tissue redox potential occur in the heart under conditions ofoxidative stress associated frequently with cardiac arrhythmias. Since beat-to-beat variability(short term variability, SV) of action potential duration (APD) is a good indicator of arrhythmiaincidence, the aim of the present work was to study the influence of redox changes on SV inisolated canine ventricular cardiomyocytes using conventional microelectrode technique. Theredox potential was shifted toward a reduced state using a reductive cocktail (containingdithiothreitol, glutathione and ascorbic acid) while oxidative changes were initiated bysuperfusion with H2O2. Redox effects were evaluated as changes in relative SV determined bycomparing SV changes to the concomitant APD changes. Exposure of myocytes to the reductivecocktail decreased SV significantly without any detectable effect on APD. Application of H2O2increased both SV and APD, but the enhancement of SV was the greater, so relative SVincreased. Longer exposure to H2O2 resulted in development of early afterdepolarizationsaccompanied by tremendously increased SV. Pretreatment with the reductive cocktail preventedboth elevation of relative SV and the development of afterdepolarizations. The results suggestthat the increased beat-to-beat variability during an oxidative stress contributes to generation ofcardiac arrhythmias.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban redox potential short term variability action potential duration beat-to-beat variability canine myocytes
Megjelenés:	Canadian Journal of Physiology and Pharmacology. - 93 : 7 (2015), p. 563-568. -
További szerzők:	Hegyi Bence (1987-) (élettanász) Váczi Krisztina (1987-) (élettanász) Horváth Balázs (1981-) (élettanász) Bányász Tamás (1960-) (élettanász) Magyar János (1961-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:	K100151 OTKA K109736 OTKA K101196 OTKA PD101171 OTKA NK104331 OTKA TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP Élettan Kutatócsoport TAMOP-4.2.4.A/2-11/1-2012-0001 TÁMOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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