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001-es BibID:	BIBFORM059231
035-os BibID:	(WoS)000324228800065 (Scopus)84883124939
Első szerző:	Vergallo, Cristian
Cím:	In Vitro Analysis of the Anti-Inflammatory Effect of Inhomogeneous Static Magnetic Field-Exposure on Human Macrophages and Lymphocytes / Cristian Vergallo, Luciana Dini, Zsuzsanna Szamosvölgyi, Bernardetta Anna Tenuzzo, Elisabetta Carata, Elisa Panzarini, János F. László
Dátum:	2013
ISSN:	1932-6203
Megjegyzések:	The effect of inhomogeneous static magnetic field (SMF)-exposure on the production of different cytokines from human peripheral blood mononuclear cells (PMBC), i.e., lymphocytes and macrophages, was tested in vitro. Some cultures were activated with lipopolysaccharide (LPS) at time point 23 h and were either left alone (positive control) or exposed to SMF continuously from 0 until 6, 18, or 24 h. The secretion of interleukin IL-6, IL-8, tumor necrosis factor TNF-alpha, and IL-10 was tested by ELISA. SMF-exposure caused visible morphological changes on macrophages as well as on lymphocytes, and also seemed to be toxic to lymphocytes ([36.58; 41.52]%, 0.308 <= p <= 0.444), but not to macrophages (<1.43%, p >= 0.987). Analysis of concentrations showed a significantly reduced production of pro-inflammatory cytokines IL-6, IL-8, and TNF-alpha from macrophages compared to negative control ([56.78; 87.52]%, p = 0.031) and IL-6 compared to positive control ([45.15; 56.03]%, p = 0.035). The production of anti-inflammatory cytokine IL-10 from macrophages and from lymphocytes was enhanced compared to negative control, significantly from lymphocytes ([-183.62; -28.75]%, p = 0.042). The secretion of IL-6 from lymphocytes was significantly decreased compared to positive control ([-115.15; -26.84]%, p = 0.039). This massive in vitro evidence supports the hypotheses that SMF-exposure (i) is harmful to lymphocytes in itself, (ii) suppresses the release of pro-inflammatory cytokines IL-6, IL-8, and TNF-alpha, and (iii) assists the production of anti-inflammatory cytokine IL-10; thus providing a background mechanism of the earlier in vivo demonstrated anti-inflammatory effects of SMF-exposure.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cytokines endotoxins lymphocytes macrophages magnetic field magnets monocytes secretion
Megjelenés:	Plos One. - 8 : 8 (2013), p. e72374-. -
További szerzők:	Dini, Luciana Szamosvölgyi Zsuzsanna Tenuzzo, Bernardetta Anna Carata, Elisabetta Panzarini, Elisa László F. János (1956-) (fizikus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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