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001-es BibID:	BIBFORM060029
Első szerző:	Jakab Éva
Cím:	Cystatin C as a potential predictor of osteoprotegerin levels in healthy men, a cross-sectional, observational study / Eva Kulcsar-Jakab, Zsofia Petho, Zoltan Pap, Edit Kalina, Roza Foldesi, Adam Balogh, Peter Antal-Szalmas, Harjit Pal Bhattoa
Dátum:	2015
ISSN:	1471-2474
Megjegyzések:	AbstractBackground: The aim of the present study is to evaluate serum osteoprotegerin (OPG) and soluble receptoractivator of nuclear factor ?B ligand (sRANKL) levels in a randomly selected male cohort over 50 years of age and itsassociation with cystatin C, a cysteine proteinase inhibitor that decreases formation of osteoclasts by interfering at alate stage of pre-osteoclast differentiation, apart from being a marker of renal function independent of gender,muscle mass and age; in addition to known predictors such as age, sex hormones, vitamin D, bone mineral density(BMD) and biochemical markers of bone turnover.Methods: We determined serum OPG and sRANKL levels and examined its relationship with cystatin C, age, osteocalcin,C-terminal telopeptides of type-I collagen, procollagen type 1 amino-terminal propeptide, 25-hydroxyvitamin D,parathyroid hormone, total 17?-estradiol (E2), total testosterone and L1?L4 (LS) and femur neck (FN) BMD data availablefrom194 (age, range: 51?81 years) randomly selected ambulatory men belonging to the HunMen cohort.Results: OPG correlated significantly with age (Spearman's rho (r) = 0.359, p < 0.001), cystatin C (r = 0.298, p < 0.001),E2 (r = 0.160, p = 0.028) and free testosterone index (FTI) (r = ?0.230, p = 0.001). Compared to the middle-aged(age: ? 59 years, n = 98), older men (age > 59 years, n = 96) had significantly higher serum OPG (4.6 pmol/L vs.5.4 pmol/L; p < 0.001), and lower sRANKL (0.226 pmol/L vs. 0.167 pmol/L; p = 0.048) levels. The older menshowed a significant correlation between serum OPG levels and cystatin C (Spearman's rho = 0.322, p = 0.002),and E2 (Spearman's rho = 0.211, p = 0.043). Including cystatin C and E2 in a regression model showed thatcystatin C (standard regression coefficient (?) = 0.345; p = 0.002) was the only significant predictor of serumOPG levels in the older men.Conclusions: The results of this study demonstrated that in addition to age (which was the stronger predictor),other modifiable factors such as cystatin C, FTI and E2 were also significant predictors of OPG, and that theassociation between cystatin C and OPG was more evident with increased age (older age group). As such,cystatin C is a significant predictor of OPG independently of age, FTI and E2.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk osteoprotegerin men cystatin c
Megjelenés:	Bmc Musculoskeletal Disorders. - 16 : 277 (2015), p. 1-7. -
További szerzők:	Pethő Zsófia (1981-) (reumatológus, immunológus) Pap Zoltán Domokos (1973-) Kalina Edit Földesi Róza (1967-) (klinikai laboratóriumi kutató, PhD hallgató) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
Pályázati támogatás:	OTKA-105073 OTKA TÁMOP-4.2.2.A-11/1/KONV-2012-0025 TÁMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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