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001-es BibID:BIBFORM061585
Első szerző:Csongrádi Éva (szakorvos)
Cím:Renal Inhibition of Heme Oxygenase-1 Increases Blood Pressure in Angiotensin II-Dependent Hypertension / Csongradi, E., Storm, M. V., Stec, D. E.
Dátum:2012
Megjegyzések:The goal of this study was to test the hypothesis that renal medullary heme oxygenase (HO) acts as a buffer against Ang-IIdependent hypertension. To test this hypothesis, renal medullary HO activity was blocked using QC-13, an imidazole-dioxolaneHO-1 inhibitor, or SnMP, a classical porphyrin based HO inhibitor. HO inhibitors were infused via IRMI catheters throughout thestudy starting 3 days prior to implantation of an osmotic minipump which delivered Ang II or saline vehicle. MAP was increasedby Ang II infusion and further increased by IRMI infusion of QC-13 or SnMP.MAP averaged 113?3, 120?7, 141?2, 153?2, and154?3mmHg in vehicle, vehicle + IRMI QC-13, Ang II, Ang II + IRMI QC-13, and Ang II + IRMI SnMP treated mice, respectively(n = 6). Inhibition of renal medullaryHO activity with QC-13 in Ang II infused mice was also associated with a significant increasein superoxide production as well as significant decreases in antioxidant enzymes catalase and MnSOD. These results demonstratethat renal inhibition of HO exacerbates Ang II dependent hypertension through a mechanism which is associated with increasesin superoxide production and decreases in antioxidant enzymes.
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Heme Oxygenase-1
Angiotensin II
Hypertension
Megjelenés:International Journal of Hypertension 2012 (2012), p. Article ID 497213. -
További szerzők:Storm, Megan V. Stec, David E.
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