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001-es BibID:	BIBFORM061613
Első szerző:	George, Eric M. (tudományos segédmunkatárs)
Cím:	Induction of Heme Oxygenase-1 Attenuates Placental Ischemia-Induced Hypertension / Eric M. George, Kathy Cockrell, Marietta Arany, Eva Csongradi, David E. Stec, Joey P. Granger.
Dátum:	2010
ISSN:	0194-911X
Megjegyzések:	Preeclampsia commonly presents as hypertension and proteinuria after the twentieth week of pregnancy. Recently, it has been recognized that the underlying mechanism in the pathophysiology of the disease is placental insufficiency and ischemia. Two mechanisms believed to be involved are the imbalance of the pro- and anti-angiogenic proteins VEGF and sFlt-1, and the production of ROS in the ischemic placenta. Heme oxygenase-1 (HO-1), a factor in the heme salvage pathway, has been shown to have beneficial effects in several models of hypertension, presumably through the production of biologically active byproducts; the vasodilatory molecule CO and the antioxidant bilirubin. Here we have utilized a rat reduced uterine perfusion pressure (RUPP) model of placental ischemia to determine if HO-1 could have beneficial effects on the disease pathology. At day 19 of pregnancy, RUPP rats showed significantly higher blood e90 Hypertension Vol 56, No 5 November 2010 Downloaded from http://hyper.ahajournals.org/ by guest on December 13, 2015 pressure than controls (1367mmHg vs. 1055mmHg respectively). Induction of HO-1 by administration of cobalt protoporphyrin (COPP) significantly reduced MAP in RUPP rats but not controls (1188 and 1045mmHg respectively). Intriguingly, normalized placental sFlt-1/ VEGF ratio, which is significantly elevated in the RUPP model versus controls (1.24.2 and 11 respectively), is significantly reduced in response to HO-1 induction (0.69.1), indicating a more pro-angiogenic phenotype. Finally, placental ROS production which is elevated nearly 4-fold in RUPP rats (953279 vs. 24471 RLU/min/mg) is significantly attenuated, though not normalized, by COPP administration (617225 RLU/min/mg). Collectively, these results suggest that induction of HO-1 or one of its biologically active metabolites might be a candidate for therapeutic intervention in preeclampsia
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt
Megjelenés:	Hypertension 56 : 5 (2010), p. e90. -
További szerzők:	Cockrell, Kathy (tudományos segédmunkatárs) Arany Marietta Csongrádi Éva (1969-) (szakorvos) Stec, David E. Granger, Joey P. (tudományos segédmunkatárs)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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