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001-es BibID:	BIBFORM065236
Első szerző:	Lázár Levente (szülész-nőgyógyász)
Cím:	Relationship of circulating cell-free DNA levels to cell-free fetal DNA levels, clinical characteristics and laboratory parameters in preeclampsia / Levente Lazar, János Rigó Jr., Bálint Nagy, Krisztián Balogh, Veronika Makó, László Cervenak, Miklós Mézes, Zoltán Prohászka, Attila Molvarec
Dátum:	2009
ISSN:	1471-2350
Megjegyzések:	Background:The aim of our study was to examine whether increased circulating total cell-freeDNA levels are related to the clinical characteristics and standard laboratory parameters ofpreeclamptic patients, to markers of inflammation, endothelial activation or injury, oxidative stressand to cell-free fetal DNA levels.Methods:Circulating total cell-free DNA was measured by real-time quantitative PCR in plasmasamples obtained from 67 preeclamptic and 70 normotensive pregnant women. Standardlaboratory parameters, C-reactive protein, plasma von Willebrand factor antigen, plasmafibronectin, plasma malondialdehyde and cell-free fetal DNA levels were also determined.Results and Conclusion:Circulating total cell-free and fetal deoxyribonucleic acid levels weresignificantly elevated in pregnancies complicated by preeclampsia (median: 11.395 vs. 32.460 and0.001 vs. 0.086 pg/?l; P < .001). The quantity of plasma total cell-free DNA did not correlate with most of the laboratory parameters, except for serum aspartate aminotransferase and alanineaminotransferase activities (correlation coefficient: 0.31; P = 0.012 and 0.46; P < .001). There was no correlation with clinical characteristics, including body mass index. The releases of both free fetal and total cell-free deoxyribonucleic acid were found to be affected in preeclampsia.Hepatocellular necrosis seems to be responsible - at least partly - for increased circulating total DNA levels in preeclampsia, as suggested by the significant correlation with liver enzyme activities
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban cell free DNA Preeclampsia clinical Characteristics
Megjelenés:	BMC Medical Genetics. - 10 (2009), p. 1-6. -
További szerzők:	Rigó János (1958-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Balogh Krisztián Makó Veronika Cervenak László Mézes Miklós Prohászka Zoltán Molvarec Attila (szülész-nőgyógyász)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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