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001-es BibID:	BIBFORM065295
Első szerző:	Nagy Bálint (molekuláris genetikus)
Cím:	Overexpression of CD24, c-myc and Phospholipase 2A in Prostate Cancer Tissue Samples Obtained by Needle Biopsy / Balint Nagy, Attila Szendroi, Imre Romics
Dátum:	2008
ISSN:	1219-4956 1532-2807
Megjegyzések:	Altered CD24, c-myc and phospholipase 2a expression was reported in different cancers. Our aim was to measure the expression of these genes in prostate cancer tissues, and compare it to non-cancerous samples. Prostate tissue samples were collected by needle biopsy from 20 prostate cancer (PCA) and 11 benign prostate hyperplasic(BPH) patients. RNA was isolated; cDNA synthetized,CD24, c-myc and phospholipase 2A(PL2A) expressionswere determined by quantitative real-time PCR method.The expression of β-globin gene was measured fornormalization of the gene expression results. Serumprostate specific antigen (PSA) levels were determined bymicroparticle enzyme immunoassay (MEIA) method. PSAlevels were significantly different between the PCA andBPH groups, 252.37 ± 308.33 ng/ml vs. 3.5 ± 2.14 ng/ml(p =0.001), respectively. CD24 expression was 988.86 ± 3041 ng/?l in prostate tumor and 4.00 ± 4.25 ng/?l in the BPH group (p=0.035). The c-myc expression was 88.32 ± 11.93 ng/?l in the prostate tumor and 17.08 ± 21.75 ng/?l in the BPH group (p=0.02), and the PL2A 31.36 ± 67.02 ng/?l was in PCA and 5.56 ± 14.08 ng/?l in BPH (p=0.025).Gleason's scores showed correlation with c-myc (p=0.019)and PSA (p=0.033) levels. Overexpression of PL2A, CD24 and c-myc was observed in prostate cancer samples using quantitative real-time PCR method.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban CD24 Overexpression prostate cancer
Megjelenés:	Pathology & Oncology Research. - 15 : 2 (2008), p. 279-283. -
További szerzők:	Szendrői Attila Romics Imre
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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