Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM065302
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:RAF-1 over-expression does condition survival of patients affected by aggressive mantle cell lymphoma / Nagy Bálint, Galimberti Sara, Benedetti Edoardo, Caracciolo Francesco, Pacini Simone, Vilpo Juhani, Ferrer Anna, Elonen Erkki, Franssila Kaarle, Knuutila Sakari, Petrini Mario
Dátum:2007
ISSN:0145-2126
Megjegyzések:Our results show over-expression of RAF-1 in MCL versus tonsilar B-cell population. The absence of significance versus normal bone marrows could be related to variability of neoplastic infiltration and, perhaps, to the microenvironment, that in MCL would be particularly relevant [11].The observation of a clinical prognostic significance of RAF-1 would be useful in the stratification of cases on the basis of a "biological risk".This would be particularly relevant in the context of the R-Hyper-CVAD regimen that, notwithstanding its high clinical efficacy (even in the eradicating minimal residual disease) has a not negligible toxicity (in our series, 30% of infective complications, with two patients who died because of sepsis).Consequently, if the prognostic role of RAF-1 over-expression will be confirmed in larger series of patients, different therapeutic strategies would be adopted in the treatment of MCL.In this line, Sorafenib, an oral multi-kinase inhibitor that targets also RAF kinases would be an interesting compound [12] for treatment of mantle cell lymphoma.
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
RAF-1
overexpression
mantle cell lymphoma
Megjelenés:Leukemia Research. - 31 : 11 (2007), p. 1595-1597. -
További szerzők:Galimberti, Sara Benedetti, Edoardo Caracciolo, Francesco Pacini, Simone Vilpo, Juhani Ferrer, Anna Elonen, Erkki Franssila, Kaarle Knuutila, Sakari Petrini, Mario
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1