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001-es BibID:	BIBFORM065336
Első szerző:	Savlı, Hakan
Cím:	Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients / Hakan Savli, Sema Sirma, Balint Nagy, Melih Aktan, Guncag Dincol, Ugur Ozbek
Dátum:	2003
ISSN:	1226-3613
Megjegyzések:	All-trans retinoic acid (ATRA) treatment of the acute promyelocytic leukemia (APL) have subsequently resulted in cell apoptosis, but the molecular mechanism of this effect remains elusive. In order to understand a possible involvement of genes regulating apoptotic signal pathways, expression levels of bcl2, bax, dapk1, myc, bad, wt1, and mcl genes were analyzed during ATRA treatment in five APL patients with t (15;17) using Real- time PCR (LightCycler). Two samples from each patient were compared to each other: primary diagnostic sample and a sample taken at remission. Effect of the ATRA treatment was demonstrated by the concomitant induction of cd14 and il1beta genes in four patients. Also other apoptosis related genes were found down-regulated in general but especially the down regulated levels of wt1 and bax attract attention. Result suggested that ATRA dependent apoptosis of APL was under the control of both internal and external pathways without relationships to the amount of the blast populations. Ratio of bcl2 to bax may be more important for this regulation than the ratio of bcl2 to bad. Either bcl2 family or less known apoptosis related genes as wt1 will still be required to further studies in this setting.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban real-time PCR ATRA apoptosis APL
Megjelenés:	Experimental And Molecular Medicine. - 35 : 5 (2003), p. 454-459. -
További szerzők:	Sirma, Sema Nagy Bálint (1956-) (molekuláris genetikus) Aktan, Melih Dincol, Guncag Ozbek, Ugur
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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