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001-es BibID:	BIBFORM065362
Első szerző:	Nagy Bálint (molekuláris genetikus)
Cím:	Detection of factor V Leiden mutation in severe pre-eclamptic Hungarian women / Balint Nagy, Tamas Tóth, Janos Rigó Jr., Istvan Karadi, Laszlo Romics, Zoltan Papp
Dátum:	1998
ISSN:	0009-9163
Megjegyzések:	Pre-eclampsia is a pregnancy-related disorder that complicates approximately 5% of all pregnancies and is cited as the primary cause of worldwide maternal and fetal mortality. The factor V Leiden mutation has been implicated in the development of severe pre-eclampsia. In order to investigate this association, a sample of 198 Hungarian women was recruited and enrolled in one of the three groups based on reproductive and health status: those as classified as pregnant and healthy (n = 71), those diagnosed as pregnant and severe pre-eclamptic (n = 69), and those found to be healthy and non-pregnant (n = 58). The presence of factor V Leiden mutation was determined by using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis (RFLP). We identified three (5.2%) heterozygous among healthy non-pregnant participants, five (7.0%) heterozygous among healthy pregnant participants and 13 (18.8%) heterozygous among pre-eclamptic women (p < 0.05, 95% CI). Our result supports the previous observation that carriers of factor V Leiden mutation are at increased risk for developing severe pre-eclampsia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban factor V Leiden mutation pre-eclamptic Hungarian
Megjelenés:	Clinical Genetics. - 53 : 6 (1998), p. 478-481. -
További szerzők:	Tóth Tamás (gyermekgyógyász) Rigó János (1958-) (szülész-nőgyógyász) Karádi István (1952-) (belgyógyász, kardiológus) Romics László Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
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