Találati lista | Tudóstér

001-es BibID:	BIBFORM065775
Első szerző:	Polgár Csaba
Cím:	The role of high-dose-rate brachytherapy boost in breast-conserving therapy : long-term results of the Hungarian National Institute of Oncology / Csaba Polgár, Levente Jánváry, Tibor Major, András Somogyi, Zoltán Takácsi-Nagy, Georgina Fröhlich, János Fodor
Dátum:	2010
ISSN:	1507-1367
Megjegyzések:	Aim: To report the long-term results of high-dose-rate (HDR) brachytherapy (BT) boost forbreast cancer patients treated with conservative surgery and radiotherapy.Materials and methods: Between 1995 and 2007, 100 early-stage breast cancer patients receivedan HDR BT boost after conservative surgery and whole breast irradiation. Ten patients (10%)received a single-fraction HDR boost of 8?10.35 Gy using rigid needles, while 90 (90%) weretreated with a fractionated multi-catheter HDR BT boost. The latter consisted of 3?4Gy(n = 19), 3?4.75 Gy (n = 70), and 2?6.4 Gy (n = 1). Breast cancer related events, cosmetic resultsand side effects were assessed.Results: At a median follow-up time of 94 months (range: 8?152) only 7 (7%) ipsilateral breastfailures were observed for a 5- and 8-year actuarial rate of 4.5 and 7.0%, respectively. The 8-year disease-free, cancer-specific, and overall survivalwas 76.1, 82.8, and 80.4%, respectively.Cosmetic outcome was rated excellent in 17%, good in 39%, fair in 33%, and poor in 11%.Data on late radiation side effects were available for 91 patients (91%). Grade 3 fibrosis andgrade 3 telangiectasia occurred in 6 (6.6%) and 2 (2.2%) patients, respectively. In univariateanalysis only positive margin status had a significant negative effect on local control.Conclusions: HDR BT boost using multi-catheter implants produce excellent long-term localtumour control with acceptable cosmetic outcome and lowrate of grade 3 late radiation sideeffects.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Reports of Practical Oncology & Radiotherapy 15 : 1 (2010), p. 1-7. -
További szerzők:	Jánváry Zsolt Levente (1977-) (orvos) Major Tibor (1970-) (biofizikus) Somogyi András Takácsi-Nagy Zoltán Fröhlich Georgina Fodor János (onkológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: