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001-es BibID:	BIBFORM066581
Első szerző:	Máthé Csaba (biológus)
Cím:	Microcystin-LR and Cylindrospermopsin Induced Alterations in Chromatin Organization of Plant Cells / Csaba Máthé, Márta M-Hamvas, Gábor Vasas
Dátum:	2013
ISSN:	1660-3397
Megjegyzések:	Cyanobacteria produce metabolites with diverse bioactivities, structures andpharmacological properties. The effects of microcystins (MCYs), a family of peptide typeprotein-phosphatase inhibitors and cylindrospermopsin (CYN), an alkaloid type of proteinsynthesis blocker will be discussed in this review. We are focusing mainly oncyanotoxin-induced changes of chromatin organization and their possible cellularmechanisms. The particularities of plant cells explain the importance of such studies.Preprophase bands (PPBs) are premitotic cytoskeletal structures important in thedetermination of plant cell division plane. Phragmoplasts are cytoskeletal structuresinvolved in plant cytokinesis. Both cyanotoxins induce the formation of multipolar spindlesand disrupted phragmoplasts, leading to abnormal sister chromatid segregation duringmitosis. Thus, MCY and CYN are probably inducing alterations of chromosome number.MCY induces programmed cell death: chromatin condensation, nucleus fragmentation,necrosis, alterations of nuclease and protease enzyme activities and patterns. The aboveeffects may be related to elevated reactive oxygen species (ROS) and/or disfunctioning ofmicrotubule associated proteins. Specific effects: MCY-LR induces histone H3hyperphosphorylation leading to incomplete chromatid segregation and the formation ofmicronuclei. CYN induces the formation of split or double PPB directly related to proteinsynthesis inhibition. Cyanotoxins are powerful tools in the study of plant cell organization.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban microcystin cylindrospermopsin cyanobacterial toxin plant chromatin microtubules
Megjelenés:	Marine Drugs. - 11 (2013), p. 3689-3717. -
További szerzők:	Mikóné Hamvas Márta (1963-) (biológus) Vasas Gábor (1975-) (biológus-vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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