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001-es BibID:BIBFORM068528
035-os BibID:(cikkazonosító)e0177003 (WOS)000400648500113 (Scopus)85019125377
Első szerző:Csutak Adrienne (szemész)
Cím:Plasminogen Activator Activity in Tears of Pregnant Women / Adrienne Csutak, Zita Steiber, József Tőzsér, Attila Jakab, András Berta, David M. Silver
Dátum:2017
ISSN:1932-6203
Megjegyzések:Purpose: Plasminogen activator activity (PAA) in tears of pregnant women wasinvestigated at various gestation times to assess the availability of plasminogenactivator for aiding potential corneal wound healing processes during pregnancy.Methods: PAA was measured by a spectrophotometric method. The analysis used 91tear samples from pregnant and non-pregnant women, supplemented with 10additional tear PAA measurements from non-pregnant women obtained in a previousstudy.Results: Tear levels of PAA in pregnant women formed a bimodal distribution. Eitherthe tear PAA level was zero or non-zero during pregnancy. When non-zero, the tearPAA level was dissociated from gestation time and not different than non-pregnant andpost-pregnant levels.The frequency of occurrence of zero level tear PAA increasedwith gestation: 16%, 17% and 46% had zero tear PAA in samples taken from women inthe first, second and third trimester,respectively.Conclusions:Overall, of the tear samples taken from women during pregnancy, a totalof 26% were at zero tear PAA. The remaining tear samples had non-zero tear PAAvalues throughout gestation equivalent to non-pregnant tear PAA values, suggestinglocal control of the source of PAA in tears. Given the importance of the plasminogenactivator system in tears to wound healing in the cornea, and the high occurrence ofzero tear PAA in our sample of pregnant women, elective corneal surgery would becontraindicated. If corneal surgery is nevertheless necessary, the tear PAA level wouldbe worth checking and patients with low level should be closely observed during thepostoperative period
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
gestation
human tears
plasminogen activator activity
pregnancy
proteolysis
tear enzymes
Megjelenés:Plos One. - 12 : 5 (2017), p. 1-10. -
További szerzők:Steiber Zita (1977-) (orvos, szemész) Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Berta András (1955-) (szemész, gyermekszemész) Silver, David M.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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