Találati lista | Tudóstér

001-es BibID:	BIBFORM068609
035-os BibID:	(cikkazonosító)6138145 (WOS)000402744300001 (Scopus)85021628120
Első szerző:	Kappelmayer János (laboratóriumi szakorvos)
Cím:	The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression / János Kappelmayer, Béla Nagy Jr.
Dátum:	2017
ISSN:	2314-6133 2314-6141
Megjegyzések:	Cellular interaction is inevitable in the pathomechanism of human disease. Formation of heterotypic cellular aggregates, between distinct cells of hematopoietic and non-hematopoietic origin, may be involved in events leading to inflammation and the complex process of cancer progression. Among adhesion receptors, the family of selectins with their ligands have been considered as one of the major contributors to cell-cell interactions. Consequently, the inhibition of the interplay between selectins and their ligands may have potential therapeutic benefits. In this review, we focus on the current evidence on the selectins as crucial modulators of inflammatory, thrombotic and malignant disorders. Knowing that there is promiscuity in selectin binding, we outline the importance of a key protein that serves as a ligand for all selectins. This dimeric mucin, the P-selectin glycoprotein ligand 1 (PSGL-1), has emerged as a major player in inflammation, thrombus and cancer development. We discuss the interaction of PSGL-1 with various selectins in physiological and pathological processes with particular emphasis on mechanisms that lead to severe disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Biomed Research International. - 2017 (2017), p. 1-18. -
További szerzők:	Nagy Béla Jr. (1980-) (labordiagnosztikai szakorvos)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: