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001-es BibID:BIBFORM069319
Első szerző:Takács László
Cím:Immature, double negative (CD4-,CD8-) rat thymocytes do not express IL-2 receptors / László Takács, Francis W. Ruscetti, Elizabeth J. Kovacs, Benedita Rocha, Stephan Brocke, Tibor Diamantstein, Bonnie J. Mathieson
Dátum:1988
Megjegyzések:IL-2R alpha-chain is expressed on a subset of mouse CD4- and CD8-, double negative (DN) thymocytes. This expression of IL-2R alpha-chain on some DN thymocytes in the mouse has led to the proposal that IL-2 might serve as a principal growth and/or differentiation factor for immature thymocytes. However, previous histologic observations have indicated that IL-2R alpha-chain is not expressed on the subcapsular thymic blasts (an area rich in DN cells) in either huma or rat thymus, whereas all three species display IL-2R expression on a few cells in the thymic medulla. Therefore, we characterized rat DN thymocytes to determine whether they contained an IL-2R+ population. The results show that rat thymic DN cells share several characteristics with mouse DN cells. However, most of the rat strains do not express the IL-2R on DN cells as shown either by immunofluorescence or by IL-2 binding and receptor cross-linking. Thus, the rare medullary IL-2R+ cells were not found in the DN cells. Only in the exceptional F344 rat strain is the IL-2R alpha-chain expressed on a major proportion of thymocytes, including both DN cells and small cortical-type thymocytes. Furthermore, rat DN cells do not contain detectable IL-2 mRNA or cytoplasmic IL-2 activity, thus supporting the conclusion that it is unlikely that IL-2 and IL-2R serve to maintain the proliferation of rat DN thymocytes in vivo. The possible significance of in vivo expression of IL-2R alpha-chain on immature thymocytes in the mouse and in a single rat strain is discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 141 : 11 (1988), p. 3810-3818. -
További szerzők:Ruscetti, Francis Kovács Erzsébet J. Rocha, Benedita Brocke, Stephan Diamantstein Tibor Mathieson, Bonnie J.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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