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001-es BibID:	BIBFORM069320
Első szerző:	Takács László
Cím:	Detection of IL-1 alpha and IL-1 beta gene expression by in situ hybridization : tissue localization of IL-1 mRNA in the normal C57BL/6 mouse / László Takács, Elizabeth J. Kovacs, Mark R. Smith, Howard A. Young, Scott K. Durum
Dátum:	1988
Megjegyzések:	IL-1 is a cytokine with a wide variety of effects on cells involved in inflammatory and immune responses, hemopoiesis, and bone formation. Many cell types have been shown to produce IL-1 in vitro; however, very little is known about the source and role of IL-1 in vivo. By using in situ hybridization, we examined the tissue distribution of cells containing IL-1 mRNA in normal C57BL/6 mice. The results show that many organs contain IL-1 mRNA-positive cells, but the highest frequency was found in lymphoid organs. The distribution and localization of these cells suggest that many of the IL-1 mRNA-producing cells are tissue macrophages. Organs exposed to environmental Ag and microbial products (lymph nodes, liver, intestine, lung, and uterus) had high frequencies of IL-1 mRNA-producing cells, suggesting that IL-1 is produced in local inflammatory or immune responses in vivo. The production of IL-1 mRNA in the thymus and in the bone marrow suggests that IL-1 is available to play physiologic roles in T cell differentiation and in hemopoiesis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Journal of Immunology 141 : 9 (1988), p. 3081-3095. -
További szerzők:	Kovács Erzsébet J. Smith, Mark R. Young, Howard A. Durum, Scott K.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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