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001-es BibID:BIBFORM069322
Első szerző:Brocke, Stephan
Cím:The ontogeny of the interleukin 2 receptor expression and of the interleukin 2 responsiveness in the rat thymus / S. Brocke, L. Takacs, J. Gerdes, H. Osawa, T. Diamantstein
Dátum:1987
ISSN:0171-2985
Megjegyzések:The ontogeny of the interleukin 2 receptor (IL 2 R) expression and of the IL 2 responsiveness has been investigated in the rat thymus. In tissue sections, IL 2 R-bearing cells were first detected at day 16 of gestation using the anti-IL 2 R mAb ART-18. In contrast to mice, IL 2 R-bearing cells of the rat are localized mainly in the thymic medulla from the first day of the corticomedullary compartimentalization, and not in the cortex. They are found in regions with a high expression of MHC class II antigens. The proportion of IL 2 R-bearing cells increases during gestation, reaches a peak at the first day after birth and declines to the adult level in the following weeks. The appearance of medullary localized IL 2 R-bearing cells is paralleled with the capacity of the thymocytes to proliferate in response to IL 2 without any additional stimuli.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunobiology 174 : 3 (1987), p. 266-273. -
További szerzők:Takács László (1955-) Gerdes, J. Osawa, Hisao Diamantstein Tibor
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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