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001-es BibID:BIBFORM069330
Első szerző:Näher, H.
Cím:Dynamics of T cells of L3T4 and Ly 2 phenotype within granulomas in murine listeriosis / H. Näher, U. Sperling, L. Takacs, H. Hahn
Dátum:1985
ISSN:0009-9104
Megjegyzések:Monoclonal antibodies anti-Ly 1, anti-Ly 2 and GK1.5 were applied to determinephenotypes of T cells within granulomas formed as a result of infection of mice with thefacultative intracellular bacterium Listeria monocytogenes. Early in granuloma formation,equal numbers of Ly 1+, Ly 2+ and L3T4+ cells were found, T cells of differentphenotypes being evenly distributed over the lesions. In mature granulomas, numbers ofLy 1 + and L3T4+ cells about doubled as compared to incipient granulomas, Ly 2+ cells,however, remained constant. Whereas Ly 1 + and L3T4+ cells within mature granulomasstill were evenly distributed, Ly 2+ cells were predominantly localized in the periphery ofthe lesions. The data indicate that both, specific Ly 2+ and L3T4+ T cells, displaycharacteristic dynamics within granulomas: Ly 2+ T cells which most likely mature fromLy 1+2+ T cells over time locate to the periphery. Concomitantly, L3T4+ T cells areenriched maintaining their distribution all over the lesions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
immunochemistry granuloma formation T cell subset monoclonal antibodies
Megjelenés:Clinical and Experimental Immunology 60 : 3 (1985), p. 559-559. -
További szerzők:Sperling, U. Takács László (1955-) Hahn, H.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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