Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM069485
Első szerző:Farkas József
Cím:Early Neurobehavioral Development of Mice Lacking Endogenous PACAP / Farkas J., Sandor B., Tamas A., Kiss P., Hashimoto H., Nagy A. D., Fulop B. D., Juhasz T., Manavalan S., Reglodi D.
Dátum:2017
Megjegyzések:Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide. In addition to its diverse physiological roles, PACAP has important functions in the embryonic development of various tissues, and it is also considered as a trophic factor during development and in the case of neuronal injuries. Data suggest that the development of the nervous system is severely affected by the lack of endogenous PACAP. Short-term neurofunctional outcome correlates with long-term functional deficits; however, the early neurobehavioral development of PACAP-deficient mice has not yet been evaluated. Therefore, the aim of the present study was to describe the postnatal development of physical signs and neurological reflexes in mice partially or completely lacking PACAP. We examined developmental hallmarks during the first 3 weeks of the postnatal period, during which period most neurological reflexes and motor coordination show most intensive development, and we describe the neurobehavioral development using a complex battery of tests. In the present study, we found that PACAP-deficient mice had slower weight gain throughout the observation period. Interestingly, mice partially lacking PACAP weighed significantly less than homozygous mice. There was no difference between male and female mice during the first 3 weeks. Some other signs were also more severely affected in the heterozygous mice than in the homozygous mice, such as air righting, grasp, and gait initiation reflexes. Interestingly, incisor teeth erupted earlier in mice lacking PACAP. Motor coordination, shown by the number of foot-faults on an elevated grid, was also less developed in PACAP-deficient mice. In summary, our results show that mice lacking endogenous PACAP have slower weight gain during the first weeks of development and slower neurobehavioral development regarding a few developmental hallmarks.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Knockout
Neurodevelopment
Neuropeptide
Reflex
Trophic factor
Megjelenés:Journal of molecular neuroscience. - 61 : 4 (2017), p. 468-478. -
További szerzők:Sándor Balázs Tamás Andrea (Idegtudomány) (Pécs) Kiss Péter (Pécs) Hashimoto, Hitoshi Nagy András Dávid Fülöp Balázs Dániel (Orvosi alapkutatások) Juhász Tamás (1976-) (biológus, orvosbiológus) Manavalan, Sridharan Reglődi Dóra (Idegtudományok)
Pályázati támogatás:K104984
OTKA
K119759
OTKA
GINOP-2.3.2-15-2016-00050
GINOP
TAMOP 4.2.4.A/2-11-1-2012-0001
TÁMOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1