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001-es BibID:	BIBFORM070808
Első szerző:	Murnyák Balázs (molekuláris biológus, genetikus)
Cím:	Genomic signature of PARP1 in glioblastoma molecular subtypes / Balázs Murnyák, Mahan C. Kouhsari, Rotem Hershkovitch, Álmos Klekner, Tibor Hortobágyi
Dátum:	2017
Megjegyzések:	Introduction: Glioblastoma (GBM) is an aggressive and frequent primary brain tumour in adults. Overexpression of PARP1 has been reported in various cancers, including GBM. Although PARP1 inhibition is a promising therapeutic target, no comprehensive analysis has addressed PARP1's expression regarding molecularheterogeneity in GBM.Aim of the study: The main objective of our study was to evaluate PARP1's associations with GBM lineage specific markers, and its transcriptomic subtypes.Material and methods: PARP1's somatic mutations, copy number alterations (CNAs), and mRNA expression, as well as survival data were collected from the ♭Glioblastoma Multiforme' TCGA dataset. A bioinformatic analysis was conducted a to evaluate PARP1's genetic signature, and prognostic role in GBM.Results: Our study revealed that PARP1 CNA gain and high mRNA expression level is a characteristic of Proneural (PN) and Classical (CL) GBM subtypes. Increased PARP1 levels exhibited an inverse correlation with patient survival (p<0.005) in the CL subgroup. ATRX (p=0.006), and TP53 (p=0.015) mutations were associated with increased PARP1 mRNA expression.Conclusions: Our study supports the therapeutic role of PARP inhibitors in GBM with the caveat that molecular heterogeneity needs to be taken into account.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok előadáskivonat Bioinformatics Oncogenetics PARP1 GBM
Megjelenés:	13th Warsaw International Medical Congress : Abstract Book / The Students' Scientific Association of the Medical University of Warsaw. - Warsaw : Medical University of Warsaw, 2017. - 242. p. -
További szerzők:	Kouhsari, Mahan C. Hershkovitch, Rotem Klekner Álmos (1970-) (idegsebész) Hortobágyi Tibor (1965-) (patológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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