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001-es BibID:BIBFORM070868
Első szerző:Márkus Bernadett (molekuláris biológus)
Cím:Analysis of the protein crosslink-profile changes and the neutrophil extracellular trap patterns elicited by different stimuli / Bernadett Márkus, Endre Kristóf, István Csomós, László Fésüs, Éva Csősz
Dátum:2017
Megjegyzések:Mature neutrophils act as a first line of defence migrating to the site of infection in response to microbial invasion. They are able to attack pathogen directly in three different ways: phagocytosis, release of antimicrobial peptides and formation of neutrophil extracellular traps (NETs). NET is the result of a unique form of cell death in which neutrophils eject their mixture of nucleoplasm and cytoplasm into the extracellular space forming a web-like structure. Hereby the invaded pathogens are trapped, neutralized therefore their dissemination is inhibited. Several antimicrobial proteins and proteases (such as neutrophil elastase, myeloperoxidase, cathepsin G, azurocidin, lactoferrin) are essential elements of the NET contributing to direct and indirect antimicrobial activities. Based on MS/MS data of protein cross-links formed in the differently treated NETs we could observe protein cross-linking by chlorinated polyamines and transglutaminases and we could demonstrate that both myeloperoxidase and TG1 are required for the stabilization of NET (Csomos et al. Cell Death Dis. 2016). Various bacteria, fungi and viruses can induce NET formation therefore we aimed to investigate the changes in the protein crosslink-profile and in the complex web-like structure during NET formation elicited by different pathogens.
Tárgyszavak:Orvostudományok Elméleti orvostudományok előadáskivonat
Megjelenés:Transglutaminases in Medicine. - p. 83.
További szerzők:Kristóf Endre (1987-) (általános orvos) Csomós István (1983-) (molekuláris biológus) Fésüs László (1947-) (orvos biokémikus) Csősz Éva (1977-) (biokémikus, molekuláris biológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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