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001-es BibID:	BIBFORM072051
Első szerző:	Korponay-Szabó Ilma (gyermekgyógyász)
Cím:	Adaptive diagnosis of coeliac disease / Korponay-Szabó Ilma R., Troncone Riccardo, Discepolo Valentina
Dátum:	2015
ISSN:	1521-6918
Megjegyzések:	Coeliac disease has for a long time simply been regarded as a gluten-dependent enteropathy and a duodenal biopsy was required in all patients for the diagnosis. It is now accepted that autoimmunity against transglutaminase 2 is an earlier, more universal and more specific feature of coeliac disease than histologic lesions. Moreover, high serum levels of combined anti-transglutaminase 2 and anti-endomysium antibody positivity have excellent predictive value for the presence of enteropathy with villous atrophy. This makes the histology evaluation of the gut no longer necessary in well defined symptomatic paediatric patients with compatible HLA-DQ2 and/or DQ8 background. The biopsy-sparing diagnostic route is not yet recommended by gastroenterologists for adults, and certain clinical circumstances (immunodeficiency conditions, extraintestinal manifestations, type-1 diabetes mellitus, age less than 2 years) may require modified diagnostic approaches. Coeliac patients with preserved duodenal villous structure do exist and these need a more extended evaluation by immunologic and molecular biology tools.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban celiac
Megjelenés:	Best Practice & Research In Clinical Gastroenterology 29 : 3 (2015), p. 381-398. -
További szerzők:	Troncone, Riccardo Discepolo, Valentina
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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