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001-es BibID:BIBFORM073211
035-os BibID:(WoS)000417778700010 (Scopus)85038218055
Első szerző:Lilleker, James B.
Cím:The EuroMyositis registry : an international collaborative tool to facilitate myositis research / James B. Lilleker, Jiri Vencovsky, Guochun Wang, Lucy R. Wedderburn, Louise Pyndt Diederichsen, Jens Schmidt, Paula Oakley, Olivier Benveniste, Maria Giovanna Danieli, Katalin Danko, Nguyen Thi Phuong Thuy, Monica Vazquez-Del Mercado, Helena Andersson, Boel De Paepe, Jan L. deBleecker, Britta Maurer, Liza J. McCann, Nicolo Pipitone, Neil McHugh, Zoe E. Betteridge, Paul New, Robert G. Cooper, William E. Ollier, Janine A. Lamb, Niels Steen Krogh, Ingrid E. Lundberg, Hector Chinoy, EuroMyositis contributors
Dátum:2018
ISSN:0003-4967
Megjegyzések:AIMS:The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data.METHODS:Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated.RESULTS:Of 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001).Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001).ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases ('V' sign: 56%?DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%.CONCLUSION:This large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Disease registrieS
Myositis
Megjelenés:Annals Of The Rheumatic Diseases. - 77 : 1 (2018), p. 30-39. -
További szerzők:Vencovsky, Jiri Wang, Guochun Wedderburn, Lucy R. Diederichsen, Louise Pyndt Schmidt, Jens Oakley, Paula Benveniste, Olivier Danieli, Maria Giovanna Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Thuy, Nguyen Thi Phuong Vazquez-Del Mercado, Monica Andersson, Helena De Paepe, Boel deBleecker, Jan L. Maurer, Britta McCann, Liza J. Pipitone, Nicolo McHugh, Neil Betteridge, Zoe New, Paul Cooper, Robert G. Ollier, William E. Lamb, Janine A. Krogh, Niels Steen Lundberg, Ingrid Chinoy, Hector EuroMyositis contributors
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