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001-es BibID:	BIBFORM073589
Első szerző:	Bodnár Ibolya
Cím:	Stress- as well as suckling-induced prolactin release is blocked by a structural analogue of the putative hypophysiotrophic prolactin-releasing factor, salsolinol / I. Bodnar, B. Mravec, L. Kubovcakova, E. B. Toth, F. Fulop, M. I. K. Fekete, R. Kvetnansky, G. M. Nagy
Dátum:	2004
ISSN:	0953-8194
Megjegyzések:	Prolactin is secreted from the anterior lobe of the pituitary gland in response both to suckling and to stress. We recently observed that 1?methyl?6,7?dihydroxy?1,2,3,4?tetrahydroisoquinoline (salsolinol), produced in the neurointermediate lobe of the pituitary gland, as well as in the medial basal hypothalamus, can selectively release prolactin from the anterior pituitary. Therefore, it has been proposed that salsolinol is a putative endogenous prolactin?releasing factor (PRF). Here, we report that one structural analogue of salsolinol, 1?methyl?3,4?dihydroisoquinoline (1MeDIQ), can block salsolinol?induced release of prolactin, but does not affect prolactin release in response to thyrotropin releasing hormone (TRH), ??methyl?p?tyrosine (?MpT) (an inhibitor of tyrosine hydroxylase), domperidone (a D2 dopamine receptor antagonist), or 5?hydroxytryptophan (5?HTP), a precursor of serotonin). 1MeDIQ profoundly inhibited suckling?, immobilization?, as well as formalin?stress induced prolactin release without any influence on corticosterone secretion. The 1MeDIQ?induced reduction in prolactin response to immobilization stress was dose?dependent. These results suggest that salsolinol can play a pivotal role in the regulation of prolactin release induced by either physiological (suckling) or environmental (stress) stimuli.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Neuroendocrinology 16 : 3 (2004), p. 208-213. -
További szerzők:	Mravec, B. Kubovcakova, L. Tóth E. Béla (1960-) (orvos) Fülöp Ferenc Fekete I. K. Márton Kvetnansky, R. Nagy György M.
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