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001-es BibID:	BIBFORM074282
Első szerző:	Biró Orsolya (molekuláris biológus)
Cím:	Non-invasive prenatal biomarkers for fetal heart defects : circulating nucleic acid and protein biomarkers in maternal blood / Orsolya Biró, Bálint Nagy
Dátum:	2018
Megjegyzések:	Background: Congenital heart defects (CHDs) are the most common fetal malformations. Prenatal ultrasonography is routinely applied for the screening of CHD but many factors influence its diagnostic accuracy. The introduction of new biomarkers could facilitate the identification of high-risk pregnancies.Objective: We reviewed expression studies of maternal blood-derived cell-free nucleic acids and proteins in pregnancies affected by CHD. NIPT techniques which enabled the detection of heart-related chromosomal aberrations were also discussed.Methods: Scientific literature databases were screened for studies where the levels of potential CHD biomarkers were measured in maternal blood samples. Available NIPT tests were collected from the providers' resources.Results: To date, there are nine CHD-associated chromosomal abnormalities (five aneuploidies, and four microdeletions) which are included in different NIPT panels. We found eight studies from which five included the analysis of specific cell-free RNA expression profile and three measurements of protein levels.Conclusion: Most of the common heart-related chromosomal aberrations can be diagnosed by NIPT. Specific cell-free RNAs and circulating proteins seem to be potential biomarkers for fetal CHDs. The application of these new biomarkers could improve the detection rate at early pregnancy, making it possible to provide optimal perinatal and perioperative management.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt congenital heart disease maternal circulation cell-free nucleic acids biomarkers
Megjelenés:	Biomedical Papers. - 162 : Suppl. 1 (2018), p. S6. -
További szerzők:	Nagy Bálint (1956-) (molekuláris genetikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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