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001-es BibID:	BIBFORM076236
035-os BibID:	(WoS)000426014800039 (Scopus)85042235833
Első szerző:	Le Fur, Mariane
Cím:	Stable and Inert Yttrium(III) Complexes with Pyclen-Based Ligands Bearing Pendant Picolinate Arms: Toward New Pharmaceuticals for β-Radiotherapy / Mariane Le Fur, Maryline Beyler, Enikő Molnár, Olivier Fougère, David Esteban-Gómez, Gyula Tircsó, Carlos Platas-Iglesias, Nicolas Lepareur, Olivier Rousseaux, Raphaël Tripier
Dátum:	2018
ISSN:	0020-1669 1520-510X
Megjegyzések:	We report the synthesis of two azaligands based on the pyclen macrocyclic platform containing two picolinate and one acetate pendant arms. The two ligands differ in the relative positions of the pendant functions, which are arranged either in a symmetrical (L3) or nonsymmetrical (L4) fashion. The complexation properties of the ligands toward natY3+ and 90Y3+ were investigated to assess their potential as chelating units for radiopharmaceutical applications. The X-ray structures of the YL3 and YL4 complexes show nonadentate binding of the ligand to the metal ions. A multinuclear 1H, 13C, and 89Y NMR study shows that the complexes present a structure in solution similar to that observed in the solid state. The two complexes present very high thermodynamic stability constants (log KYL = 23.36(2) and 23.07(2) for YL3 and YL4, respectively). The complexes also show a remarkable inertness with respect to their proton-assisted dissociation, especially YL4. 90Y radiolabeling was proved to be efficient under mild conditions. The 90YL3 and 90YL4 radiochelates were found to be more stable than 90Y(DOTA).
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Yttrium(III) Pyclen-Based Ligand Picolinate β-Radiotherapy
Megjelenés:	Inorganic Chemistry. - 57 : 4 (2018), p. 2051-2063. -
További szerzők:	Beyler, Maryline Molnár Enikő (1991-) (vegyész) Fougère, Olivier Esteban-Gómez, David Tircsó Gyula (1977-) (vegyész, kémia tanár) Platas-Iglesias, Carlos Lepareur, Nicolas Rousseaux, Olivier Tripier, Raphaël
Pályázati támogatás:	K-120224 project OTKA ÚNKP-17-3 Egyéb GINOP-2.3.2-15-2016-00008 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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