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001-es BibID:	BIBFORM076862
035-os BibID:	(cikkazonosító)e0211433 (WOS)000457037500170 (Scopus)85060512660
Első szerző:	Ivic, Ivan
Cím:	VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice / Ivan Ivic, Marta Balasko, Balazs D. Fulop, Hitoshi Hashimoto, Gabor Toth, Andrea Tamas, Tamas Juhasz, Akos Koller, Dora Reglodi, Margit Solymár
Dátum:	2019
ISSN:	1932-6203
Megjegyzések:	PACAP and VIP are closely related neuropeptides with wide distribution and potent effect in the vasculature. We previously reported vasomotor activity in peripheral vasculature of male wild type (WT) and PACAP-deficient (KO) mice. However, female vascular responses are still unexplored. We hypothesized that PACAP-like activity is maintained in female PACAP KO mice and the mechanism through which it is regulated differs from that of male PACAP KO animals. METHODS: We investigated the vasomotor effects of VIP and PACAP isoforms and their selective blockers in WT and PACAP KO female mice in carotid and femoral arteries. The expression and level of different PACAP receptors in the vessels were measured by RT-PCR and Western blot. RESULTS: In both carotid and femoral arteries of WT mice, PACAP1-38, PACAP1-27 or VIP induced relaxation, without pronounced differences between them. Reduced relaxation was recorded only in the carotid arteries of KO mice as compared to their WT controls. The specific VPAC1R antagonist completely blocked the PACAP/VIP-induced relaxation in both arteries of all mice, while PAC1R antagonist affected relaxation only in their femoral arteries. CONCLUSION: In female WT mice, VPAC1 receptors appear to play a dominant role in PACAP-induced vasorelaxation both in carotid and in femoral arteries. In the PACAP KO group PAC1R activation exerts vasorelaxation in the femoral arteries but in carotid arteries there is no significant effect of the activation of this receptor. In the background of this regional difference, decreased PAC1R and increased VPAC1R availability in the carotid arteries was found.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Plos One. - 14 : 1 (2019), p. e0211433. -
További szerzők:	Balaskó Márta Fülöp Balázs Dániel (Orvosi alapkutatások) Hashimoto, Hitoshi Tóth Gábor (Szeged) Tamás Andrea (Idegtudomány) (Pécs) Juhász Tamás (1976-) (biológus, orvosbiológus) Koller Ákos Reglődi Dóra (Idegtudományok) Solymár Margit
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-15 2017-00008 EFOP EFOP-3.6.3-VEKOP-16-2017-00009 EFOP K115874 OTKA K104984 OTKA K119759 OTKA KTIA_13_NAP-A-III/5 Egyéb GINOP-2.3.2-15-2016-00050 "PEPSYS" GINOP TÁMOP-4.2.4.A/2-11-1-2012-0001 TÁMOP
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