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001-es BibID:	BIBFORM077207
Első szerző:	Balogh Emese (reumatológus)
Cím:	Angiogenesis in inflammatory arthritis / Emese Balogh, Monika Biniecka, Ursula Fearon, Douglas J. Veale, Zoltán Szekanecz
Dátum:	2019
Megjegyzések:	Angiogenesis is the outgrowth of new vessels from existing ones and is an early event in the inflamed joint tissue. It is governed by a tightly controlled balance of pro- and anti-angiogenic stimuli, which promote or inhibit generation and proliferation of new endothelial cells, vascular morphogenesis and vessel remodelling. De novo capillary formation is crucial in maintaining the supply of various nutrients as well as oxygen to the inflamed tissue. Local and systemic expression of angiogenic factors may indicate a constant remodelling of synovial vasculature. Redox signalling is closely related to angiogenesis and can alter angiogenic responses of synovial cells. In this review we discuss key issues about the endothelial pathology in inflammatory arthritis followed by review of angiogenic processes and main angiogenic mediators. We discuss the hypoxia-VEGF-Ang/Tie2 system and its related therapeutic implications in detail with further review of various mediator protein targets and intracellular regulatory pathway targets with their current and potential future role in preclinical or clinical setting whilst ameliorating inflammation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Israel Medical Association Journal. - 21 (2019), p. 345-352. -
További szerzők:	Biniecka, Monika Fearon, Ursula Veale, Douglas J. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL
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