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001-es BibID:	BIBFORM081249
035-os BibID:	(PMID)30522694
Első szerző:	Cuenca, Marta
Cím:	CD84 cell surface signaling molecule : an emerging biomarker and target for cancer and autoimmune disorders / Marta Cuenca, Jordi Sintes, Árpád Lányi, Pablo Engel
Dátum:	2019
ISSN:	1521-6616
Megjegyzések:	CD84 (SLAMF5) is a member of the SLAM family of cell-surface immunoreceptors. Broadly expressed on most immune cell subsets, CD84 functions as a homophilic adhesion molecule, whose signaling can activate or inhibit leukocyte function depending on the cell type and its stage of activation or differentiation. CD84-mediated signaling regulates diverse immunological processes, including T cell cytokine secretion, natural killer cell cytotoxicity, monocyte activation, autophagy, cognate T:B interactions, and B cell tolerance at the germinal center checkpoint. Recently, alterations in CD84 have been related to autoimmune and lymphoproliferative disorders. Specific allelic variations in CD84 are associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In chronic lymphocytic leukemia, CD84 mediates intrinsic and stroma-induced survival of malignant cells. In this review, we describe our current understanding of the structure and function of CD84 and its potential role as a therapeutic target and biomarker in inflammatory autoimmune disorders and cancer.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Autoimmune disorders Autophagy CD84 Chronic lymphocytic leukemia (CLL) Disease biomarkers Germinal center (GC) SLAM family receptors
Megjelenés:	Clinical Immunology. - 204 (2019), p. 43-49. -
További szerzők:	Sintes, Jordi Lányi Árpád (1962-) (biológus, immunológus) Engel, Pablo
Pályázati támogatás:	K-109444 NKFIH
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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