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001-es BibID:
BIBFORM083251
035-os BibID:
(WoS)000569215300024 (Scopus)85081546031
Első szerző:
Martinelli, Massimo
Cím:
Vaccinations and Immunization Status in Pediatric Inflammatory Bowel Disease : a Multicenter Study From the Pediatric IBD Porto Group of the ESPGHAN / Massimo Martinelli, Francesca Paola Giugliano, Caterina Strisciuglio, Vaidotas Urbonas, Daniela Elena Serban, Aleksandra Banaszkiewicz, Amit Assa, Iva Hojsak, Tereza Lerchova, Víctor Manuel Navas-López, Claudio Romano, Małgorzata Sladek, Gabor Veres, Marina Aloi, Ruta Kucinskiene, Erasmo Miele, Open IBD Interest Group of the ESPGHAN
Dátum:
2020
ISSN:
1078-0998
Megjegyzések:
BACKGROUND: Vaccine-preventable diseases and opportunistic infections in pediatric inflammatory bowel disease (IBD) are increasingly recognized issues. The aims of this study were to evaluate vaccinations, immunization status, and consequent therapeutic management in children with IBD and to analyze the differences among patients diagnosed before (Group 1) and after June 2012 (Group 2). METHODS: This was a multicenter, retrospective cohort investigation. Between July 2016 and July 2017, 430 children with IBD were enrolled in 13 centers. Diagnosis, therapeutic history, vaccinations, and immunization status screening at diagnosis and at immunosuppressant (IM)/biologic initiation and reasons for incomplete immunization were retrieved. RESULTS: Vaccination rates at diagnosis were unsatisfactory for measles, mumps, and rubella (89.3%), Haemophilus influenzae (81.9%), meningococcus C (23.5%), chickenpox (18.4%), pneumococcus (18.6%), papillomavirus (5.9%), and rotavirus (1.9%). Complete immunization was recorded in 38/430 (8.8%) children, but specific vaccines were recommended in 79/430 patients (18.6%), without differences between the 2 groups. At IM start, 22% of children were tested for Epstein-Barr virus (EBV) status, with 96.2% of EBV-naïve patients starting azathioprine, without differences between Groups 1 and 2. Screening for latent tuberculosis (TB) before start of biologics was performed in 175/190 (92.1%), with up to 9 different screening strategies and numerous inconsistencies. CONCLUSIONS: We demonstrated a poor immunization status at diagnosis in children with IBD, which was not followed by proper vaccination catch-up. EBV status before IM initiation and latent TB before biologics were not adequately assessed. Thus, the overall impact of the current guidelines seems unsatisfactory.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
Inflammatory Bowel Diseases. - 26 : 9 (2020), p. 1407-1414. -
További szerzők:
Giugliano, Francesca Paola
Strisciuglio, Caterina
Urbonas, Vaidotas
Serban, Daniela Elena
Banaszkiewicz, Aleksandra
Assa, Amit
Hojsak, Iva
Lerchova, Tereza
Navas-López, Víctor Manuel
Romano, Claudio
Sladek, Małgorzata
Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus)
Aloi, Marina
Kucinskiene, Ruta
Miele, Erasmo
Open IBD Interest Group of the ESPGHAN
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