Találati lista | Tudóstér

001-es BibID:	BIBFORM086757
035-os BibID:	(cikkazonosító)99 (WoS)000580817500001 (Scopus)85090741312
Első szerző:	Kovács Renátó László (molekuláris biológus)
Cím:	Fungal Quorum-Sensing Molecules : a Review of Their Antifungal Effect against Candida Biofilms / Renátó Kovács, László Majoros
Dátum:	2020
Megjegyzések:	The number of effective therapeutic strategies against biofilms is limited; development of novel therapies is urgently needed to treat a variety of biofilm-associated infections. Quorum sensing is a special form of microbial cell-to-cell communication that is responsible for the release of numerous extracellular molecules, whose concentration is proportional with cell density. Candida-secreted quorum-sensing molecules (i.e., farnesol and tyrosol) have a pivotal role in morphogenesis, biofilm formation, and virulence. Farnesol can mediate the hyphae-to-yeast transition, while tyrosol has the opposite effect of inducing transition from the yeast to hyphal form. A number of questions regarding Candida quorum sensing remain to be addressed; nevertheless, the literature shows that farnesol and tyrosol possess remarkable antifungal and anti-biofilm effect at supraphysiological concentration. Furthermore, previous in vitro and in vivo data suggest that they may have a potent adjuvant effect in combination with certain traditional antifungal agents. This review discusses the most promising farnesol- and tyrosol-based in vitro and in vivo results, which may be a foundation for future development of novel therapeutic strategies to combat Candida biofilms.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Fungi. - 6 : 3 (2020), p. 99. -
További szerzők:	Majoros László (1966-) (szakorvos, klinikai mikrobiológus)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00009 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: