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001-es BibID:	BIBFORM087942
Első szerző:	Dömötör Johanna (neurológus)
Cím:	Decrease of global current source density predicts successful treatment in absence and juvenile myoclonic epilepsies / Johanna Dömötör, Béla Clemens, Szilvia Puskás, István Fekete
Dátum:	2017
ISSN:	0920-1211
Megjegyzések:	Objective: To investigate relationship between treatment efficiency and EEG background activity changes in absence epilepsy (AE) and juvenile myoclonic epilepsy (JME) patients. Patients and methods: EEGs of 31 patients were analysed before treatment and after six months of treatment. Three minutes of artifact-free waking EEG background activity (without epileptiform potentials) were analysed for each patient in both conditions. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography). Average of all the voxel-wise current source density (CSD) values within the 0.5?8.0 Hz frequency range was computed for each EEG. Fischer's exact test was used to investigate association between the global CSD changes and the therapeutic outcome. Results: Tight connection was demonstrated between seizure freedom and decreased CSD, and between persisting seizures and increased CSD (p < 0.001). Significance: An EEG-based biomarker that predicts successful drug treatment was described.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Epilepsy Research. - 133 (2017), p. 1-5. -
További szerzők:	Clemens Béla (1950-) (neurológus) Puskás Szilvia (1979-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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