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001-es BibID:	BIBFORM089119
Első szerző:	Várnagy Katalin (vegyész)
Cím:	Equilibrium and structural studies on copper(II) complexes of tetra-, penta- and hexa-peptides containing histidyl residues at the C-termini / Katalin Várnagy, Julianna Szabó, Imre Sóvágó, Gerasimos Malandrinos, Nick Hadjiliadis, Daniele Sanna, Giovanni Micera
Dátum:	2000
ISSN:	0300-9246 1364-5447
Megjegyzések:	The stoichiometry, stability constants and solution structure of the complexes formed in the reaction of copper(II) with oligopeptides containing histidyl residues at the C-termini (Gly(3)His, Gly(4)His and Gly(5)His) have been determined by potentiometric, UV-VIS and EPR spectroscopic methods. The formation of the species [CuHL](2+), [CuL](+), [CuH-1L], [CuH-2L](-) and [CuH-3L](2-) was detected in all cases. Binding modes of the species [CuL](+), [CuH-1L] and [CuH-2L](-) were characterized by the metal ion co-ordination of the terminal amino group, carbonyl oxygen or one or two deprotonated amide nitrogens in joined five-membered chelates from the N-termini, while the fourth co-ordination site of the metal ion was occupied by nitrogen donors of imidazole in the form of a macrochelate. The stability of the macrochelate was decreased upon increasing the length of the peptide molecule. For the penta- and hexa-peptides the species [CuH-3L](2-) was characterized as a 4N-complex with equatorial co-ordination of the terminal amino group and subsequent three deprotonated amide nitrogens, with unco-ordinated imidazolyl residues, while a 5N-species was suggested to form for Gly(3)His with axial interaction of the imidazole-N donor atom. Copper(II) complexes of Gly(2)His and pentaglycine were also investigated for reliable comparison.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of the Chemical Society. Dalton Transactions. - 2000 : 4 (2000), p. 467-472. -
További szerzők:	Szabó Julianna (vegyész) Sóvágó Imre (1946-) (vegyész) Malandrinos, Gerasimos Hadjiliadis, Nick Sanna, Daniele (1956-) (vegyész) Micera, Giovanni
Pályázati támogatás:	OTKA-T19337 OTKA TéT GR-1/96 egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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