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001-es BibID:BIBFORM091345
Első szerző:Szöőr Árpád (orvos)
Cím:From antibodies to living drugs : quo vadis cancer immunotherapy? / Szöőr Árpád, Szöllősi János, Vereb György
Dátum:2021
ISSN:2676-8615 2676-8607
Megjegyzések:In the last few decades, monoclonal antibodies targeting various receptors and ligands have shown signifcant advance in cancer therapy. However, still a great percentage of patients experiences tumor relapse despite persistent antigen expression. Immune cell therapy with adoptively transferred modifed T cells that express chimeric antigen receptors (CAR) is an engaging option to improve disease outcome. Designer T cells have been applied with remarkable success in the treatment for acute B cell leukemias, yielding unprecedented antitumor activity and signifcantly improved overall survival. Relying on the success of CAR T cells in leukemias, solid tumors are now emerging potential targets; however, their complexity represents a signifcant challenge. In preclinical models, CAR T cells recognized and efciently killed the wide spectrum of tumor xenografts; however, in human clinical trials, limited antitumor efcacy and serious side efects, including cytokine release syndrome, have emerged as potential limitations. The next decade will be an exciting time to further optimize this novel cellular therapeutics to improve efector functions and, at the same time, keep adverse events in check. Moreover, we need to establish whether gene-modifed T cells which are yet exclusively used for cancer patients could also be successful in the treatment for other diseases. Here, we provide a concise overview about the transition from monoclonal antibodies to the generation of chimeric antigen receptor T cells. We summarize lessons learned from preclinical models, including our own HER2-positive tumor models, as well as from clinical trials worldwide. We also discuss the challenges we are facing today and outline future prospects
taa, km
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Chimeric autoantibody receptor
Immunotherapy
Chimeric antigen receptor
Bispecifc antibody
Cell therapy
Humanized antibody
Megjelenés:Biologia Futura. - 72 : 1 (2021), p. 85-99. -
További szerzők:Szöllősi János (1953-) (biofizikus) Vereb György (1965-) (biofizikus, orvos)
Pályázati támogatás:K119690
OTKA
FK132773
OTKA
GINOP-2.3.2-15-2016-00044
GINOP
Egyéb
MTA
ÚNKP-20-5-DE-48
Egyéb
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