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001-es BibID:	BIBFORM096223
035-os BibID:	(cikkazonosító)206 (scopus)85112712420 (wos)000686714500001
Első szerző:	Fábián Ákos István (aneszteziológus)
Cím:	Carboxymethyl-γ-cyclodextrin, a novel selective relaxant binding agent for the reversal of neuromuscular block induced by aminosteroid neuromuscular blockers : an ex vivo laboratory study / Ákos I. Fábián, Edömér Tassonyi, Vera Csernoch, Marianna Fedor, Tamás Sohajda, Lajos Szente, Béla Fülesdi1
Dátum:	2021
ISSN:	1471-2253
Megjegyzések:	Background Residual neuromuscular block at the end of surgery may compromise the patient's safety. The risk of airway complications can be minimized through monitoring of neuromuscular function and reversal of neuromuscular block if needed. Effective reversal can be achieved with selective relaxant binding agents, however, sugammadex is the only clinically approved drug in this group. We investigated the concentration?response properties of a novel selective relaxant binding agent, carboxymethyl-?-cyclodextrin for the reversal of neuromuscular block. We evaluated the hypothesis that it is equally potent for reversing neuromuscular block as sugammadex. Methods Phrenic nerve ? hemidiaphragm tissue preparations were isolated from male Wistar rats and suspended in a tissue holder allowing electrical stimulation of the nerve and monitoring of muscle contraction force. Concentration?response relationships were constructed for the neuromuscular blocking agents rocuronium, pipecuronium, and vecuronium. The half-effective concentrations of sugammadex and carboxymethyl-?-cyclodextrin for reversal of neuromuscular block were determined. Results The half effective concentrations (95% confidence interval, CI) were 7.50 (6.93?8.12) ?M for rocuronium, 1.38 (1.33?1.42) ?M for pipecuronium, and 3.69 (3.59?3.80) ?M for vecuronium. The half effective concentrations (95% CI) of carboxymethyl-?-cyclodextrin and sugammadex were 35.89 (32.67?39.41) ?M and 3.67 (3.43?3.92) ?M, respectively, for the reversal of rocuronium-induced block; 10.14 (9.61?10.70) ?M and 0.67 (0.62?0.74) ?M, respectively, for the reversal of pipecuronium-induced block; and 376.1 (341.9?413.8) ?M and 1.45 (1.35?1.56) ?M, respectively, for the reversal of vecuronium-induced block. Conclusions Carboxymethyl-?-cyclodextrin is an effective, but less potent agent for reversal of neuromuscular block than sugammadex.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Neuromuscular blocking agent Selective relaxant binding agent Cyclodextrin Sugammadex Rocuronium Pipecuronium Vecuronium Phrenic nerve Hemidiaphragm
Megjelenés:	BMC Anesthesiology. - 21 : 1 (2021), p. 1-9. -
További szerzők:	Tassonyi Edömér (1940-2022) (aneszteziológus) Csernoch Vera (1987-) (orvos) Fedor Marianna Sohajda Tamás Szente Lajos (1951-) (vegyész) Fülesdi Béla (1961-) (aneszteziológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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