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001-es BibID:	BIBFORM096382
035-os BibID:	(cikkazonosító)881
Első szerző:	Lőrincz Hajnalka (biológus)
Cím:	Low Levels of Serum Fetuin-A and Retinol-Binding Protein 4 Correlate with Lipoprotein Subfractions in Morbid Obese and Lean Non-Diabetic Subjects / Hajnalka Lőrincz, Imre Csige, Mariann Harangi, Anita Szentpéteri, Ildikó Seres, Zoltán Szabó, György Paragh, Sándor Somodi
Dátum:	2021
ISSN:	2075-1729
Megjegyzések:	Background: Fetuin-A and retinol-binding protein 4 (RBP4) are secreted as both hepatokine and adipokine. These are involved in insulin resistance, obesity-related dyslipidemia, and atherosclerosis. To date, correlations of circulating fetuin-A and RBP4 with lipoprotein subfractions as well as high-density lipoprotein (HDL)-linked proteins have not been entirely investigated in morbid obese and lean non-diabetic subjects. Methods: One-hundred obese non-diabetic patients (body mass index, BMI: 42.5 +- 8.1 kg/m2) along with 32 gender and age-matched normal weight controls (BMI: 24.5 +- 2.5 kg/m2) were enrolled in our study. Serum fetuin-A and RBP4 were measured by ELISA. Lipoprotein subfractions were distributed by Lipoprint gelelectrophoresis. Results: Serum fetuin-A and RBP4 were unexpectedly lower in obese patients (p < 0.01 and p < 0.01, respectively) compared to controls and correlated with each other (r = 0.37; p < 0.001). Fetuin-A had positive correlations with HDL-C (r = 0.22; p = 0.02), apolipoprotein AI (apoAI) (r = 0.33; p < 0.001), very-low density lipoprotein (VLDL) subfraction (r = 0.18; p = 0.05), and large HDL subfraction levels (r = 0.3; p = 0.001) but did not show correlation with carbohydrate parameters in all subjects. RBP4 correlated positively with HDL-C (r = 0.2; p = 0.025), apoAI (r = 0.23; p = 0.01), VLDL subfraction (r = 0.37; p < 0.001), intermediate HDL subfraction (r = 0.23; p = 0.01), and small HDL subfraction (r = 0.21; p = 0.02) concentrations, as well as C-peptide levels in overall participants. Backward stepwise multiple regression analysis showed that serum fetuin-A concentration is best predicted by RBP4 and large HDL subfraction. In model 2, VLDL subfraction was the independent predictor of serum RBP4 level. Conclusions: Our data may indicate a potential role of fetuin-A and RBP4 in impaired lipoprotein metabolism associated with obesity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk fetuin-A retinol-binding protein 4 lipoprotein obesity insulin resistance diabetes
Megjelenés:	Life. - 11 : 9 (2021), p. 1-13. -
További szerzők:	Csige Imre (1985-) (orvos) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Szentpéteri Anita (1988-) (biológus) Seres Ildikó (1954-) (biokémikus) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Paragh György (1953-) (belgyógyász) Somodi Sándor (1977-) (belgyógyász)
Pályázati támogatás:	NKFIH K115723 egyéb NKFIH PD124126 egyéb GINOP-2.3.2-15-2016-00005 GINOP
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