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001-es BibID:BIBFORM096506
Első szerző:Iversen, Rasmus
Cím:Efficient T cell-B cell collaboration guides autoantibody epitope bias and onset of celiac disease / Iversen Rasmus, Roy Bishnudeo, Stamnaes Jorunn, Hydahl Lene S., Hnida Kathrin, Neumann Ralf S., Korponay-Szabó Ilma R., Lundin Knut E. A., Sollid Ludvig M.
Dátum:2019
ISSN:0027-8424 1091-6490
Megjegyzések:B cells play important roles in autoimmune diseases through autoantibody production, cytokine secretion, or antigen presentation to T cells. In most cases, the contribution of B cells as antigenpresenting cells is not well understood. We have studied the autoantibody response against the enzyme transglutaminase 2 (TG2) in celiac disease patients by generating recombinant antibodies from single gut plasma cells reactive with discrete antigen domains and by undertaking proteomic analysis of anti-TG2 serum antibodies. The majority of the cells recognized epitopes in the Nterminal domain of TG2. Antibodies recognizing C-terminal epitopes interfered with TG2 cross-linking activity, and B cells specific for Cterminal epitopes were inefficient at taking up TG2-gluten complexes for presentation to gluten-specific T cells. The bias toward N-terminal epitopes hence reflects efficient T-B collaboration. Production of antibodies against N-terminal epitopes coincided with clinical onset of disease, suggesting that TG2-reactive B cells with certain epitope specificities could be the main antigen-presenting cells for pathogenic, gluten-specific T cells. The link between B cell epitopes, antigen presentation, and disease onset provides insight into the pathogenic mechanisms of a T cell-mediated autoimmune condition.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
celiac disease
B cells
antigen presentation
autoantibodies
celiac disease
Megjelenés:Proceedings Of The National Academy Of Sciences Of The United States Of America. - 116 : 30 (2019), p. 15134-15139. -
További szerzők:Roy, Bishnudeo Stamnaes, Jorunn Hydahl, Lene S. Hnida, Kathrin Neumann, Ralf S. Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Lundin, Knut Erik Aslaksen Sollid, Ludvig M.
Pályázati támogatás:120392
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