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001-es BibID:	BIBFORM096508
035-os BibID:	(cikkazonosító)4190 (scopus)85104354708 (wos)000644300400001
Első szerző:	Bencze Dóra
Cím:	Type I Interferon Production of Plasmacytoid Dendritic Cells under Control / Bencze Dóra, Fekete Tünde, Pázmándi Kitti
Dátum:	2021
ISSN:	1661-6596 1422-0067
Megjegyzések:	One of the most powerful and multifaceted cytokines produced by immune cells are type I interferons (IFNs), the basal secretion of which contributes to the maintenance of immune homeostasis, while their activation-induced production is essential to effective immune responses. Although, each cell is capable of producing type I IFNs, plasmacytoid dendritic cells (pDCs) possess a unique ability to rapidly produce large amounts of them. Importantly, type I IFNs have a prominent role in the pathomechanism of various pDC-associated diseases. Deficiency in type I IFN production increases the risk of more severe viral infections and the development of certain allergic reactions, and supports tumor resistance; nevertheless, its overproduction promotes autoimmune reactions. Therefore, the tight regulation of type I IFN responses of pDCs is essential to maintain an adequate level of immune response without causing adverse effects. Here, our goal was to summarize those endogenous factors that can influence the type I IFN responses of pDCs, and thus might serve as possible therapeutic targets in pDC-associated diseases. Furthermore, we briefly discuss the current therapeutic approaches targeting the pDC-type I IFN axis in viral infections, cancer, autoimmunity, and allergy, together with their limitations defined by the Janus-faced nature of pDC-derived type I IFNs.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk plasmacytoid dendritic cells type I interferon regulation antiviral response viral infection cancer autoimmunity allergy IFN gene signature therapy
Megjelenés:	International Journal Of Molecular Sciences. - 22 : 8 (2021), p. 1-47. -
További szerzők:	Fekete Tünde (1984-) (immunológus, molekuláris biológus, mikrobiológus) Pázmándi Kitti Linda (1984-) (molekuláris biológus, immunológus)
Pályázati támogatás:	FK 128294 OTKA PD 135193 OTKA GINOP-2.3.2-15-2016-00050 GINOP ÚNKP-20-05-DE-3 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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