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001-es BibID:BIBFORM096511
Első szerző:Riznik, Petra
Cím:Diagnostic Delays in Children With Coeliac Disease in the Central European Region / Riznik Petra, De Leo Luigina, Dolinsek Jasmina, Gyimesi Judit, Klemenak Martina, Koletzko Berthold, Koletzko Sibylle, Korponay-Szabó Ilma Rita, Krencnik Tomaz, Not Tarcisio, Palcevski Goran, Sblattero Daniele, Vogrincic Matej, Werkstetter Katharina Julia, Dolinsek Jernej
Dátum:2019
ISSN:0277-2116
Megjegyzések:Objectives: Coeliac disease (CD) is a systemic autoimmune disorder affecting about 1% of the population. Many patients remain undiagnosed or are diagnosed with substantial delay. We assessed diagnostic delays in symptomatic CD children in Central Europe (CE). Methods: Paediatric gastroenterologists in 5 CE countries retrospectively reported data of their patients diagnosed in 2016. Age at first CD-related symptom(s), first visit to paediatric gastroenterologist and confirmed diagnosis were used to determine diagnostic delays. Results: Data from 393 children (65% girls, median age 7 years, range 7 months to 18.5 years) from Croatia, Hungary, Germany, Italy, and Slovenia were analysed. Median duration from first symptom(s) to visit to paediatric gastroenterologist was 5 months (range 0-10 years; preschool 4 months, school-aged 5 months), and further duration until final diagnosis was 1 month (range 0-5 years) with significant regional differences (P < 0.001). Median diagnostic delay was 6 months (range 0-10 years; preschool 5 months, school-aged 7 months). Type of clinical presentation had little, however, significant effect on delays. Reduced body mass in delays longer than 3 years compared with delays shorter than 1 year was found (z score -0.93 vs -0.39, P < 0.05). Conclusions: Time from first symptoms to CD diagnosis in children in 5 CE countries is slightly shorter compared with few other small paediatric studies, and significantly shorter than reported for adults. Nevertheless, delays of more than 3 years in 6.6% of children are worrisome. Raising awareness about the variable symptoms and implementation of reliable diagnostic tools will further reduce diagnostic delays.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
coeliac disease
diagnostic delay
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 69 : 4 (2019), p. 443-448. -
További szerzők:De Leo, Luigina Dolinsek, Jasmina Gyimesi Judit Klemenak, Martina Koletzko, Berthold Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Krencnik, Tomaz Not, Tarcisio Palcevski, Goran Sblattero, Daniele Vogrincic, Matej Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Dolinśek, Jernej
Pályázati támogatás:Interreg Central Europe CE111
Egyéb
EFOP-3.6.1-16-2016-00022
EFOP
NKFIH 120392
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