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001-es BibID:BIBFORM096519
035-os BibID:(cikkazonosító)1594 (WoS)000662368300001 (Scopus)85105759721
Első szerző:Nurmi, Rakel
Cím:Celiac Disease-Type Tissue Transglutaminase Autoantibody Deposits in Kidney Biopsies of Patients with IgA Nephropathy / Nurmi Rakel, Korponay-Szabó Ilma, Laurila Kaija, Huhtala Heini, Niemelä Onni, Mustonen Jukka, Mäkelä Satu, Kaukinen Katri, Lindfors Katri
Dátum:2021
ISSN:2072-6643
Megjegyzések:An association between celiac disease and IgA nephropathy (IgAN) has been suggested. In celiac disease, in addition to circulating in serum, IgA-class tissue transglutaminase (tTG) autoantibodies are deposited in the small bowel mucosa and extraintestinal organs. In this case series of IgAN patients with or without celiac disease, we studied whether celiac disease-type IgA-tTG deposits occur in kidney biopsies. The study included nine IgAN patients, four of them with celiac disease. At the time of the diagnostic kidney biopsy serum tTG autoantibodies were measured and colocalization of IgA and tTG was investigated in the frozen kidney biopsies. Three IgAN patients with celiac disease had IgA-tTG deposits in the kidney even though in two of these the celiac disease diagnosis had been set years later. These deposits were not found in a patient with already diagnosed celiac disease following a gluten-free diet. Of the five non-celiac IgAN patients, three had IgA-tTG deposits in the kidney. We conclude that tTG-targeted IgA deposits can be found in the kidney biopsies of gluten-consuming IgAN patients but their specificity to celiac disease seems limited
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
celiac disease
IgA nephropathy
tissue transglutaminase autoantibody
tissue transglutaminase-targeted IgA deposits
Megjelenés:Nutrients. - 13 : 5 (2021), p. 1-8. -
További szerzők:Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Laurila, Kaija Huhtala, Heini Niemelä, Onni Mustonen, Jukka Mäkelä, Satu Kaukinen, Katri Lindfors, Katri
Pályázati támogatás:NKFIH 120392
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