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001-es BibID:	BIBFORM096523
Első szerző:	Szebeni Beáta
Cím:	Increased Expression of Serum- and Glucocorticoid-regulated Kinase-1 in the Duodenal Mucosa of Children With Coeliac Disease / Szebeni Beáta, Vannay Ádám, Sziksz Erna, Prókai Ágnes, Cseh Áron, Veres Gábor, Dezsőfi Antal, Győrffy Hajnalka, Korponay-Szabó I. R., Arató András
Dátum:	2010
ISSN:	0277-2116
Megjegyzések:	Objectives: Enterocyte apoptosis induced by activated intraepithelial lymphocytes is increased in coeliac disease (CD). Serum- and glucocorticoid-regulated kinase-1 (SGK1) is a serine/threonine protein kinase that may inhibit apoptosis and compensate for the excessive death of surface epithelial cells. The significance of SGK1 in CD is elusive so far. The aim of this study was to characterise the expression and localisation of SGK1 in duodenal biopsy samples taken from children with untreated CD, children with treated CD, and controls. Patients and methods: Duodenal biopsy specimens were collected from 16 children with untreated CD, 9 children with treated CD, and 10 controls. The mRNA expression of SGK1 was determined by real-time reverse transcription-polymerase chain reaction. SGK1 and phosphorylated (P)-SGK1 protein levels and their localisation were determined by Western blot and immunofluorescent staining, respectively. Results: We found increased SGK1-mRNA expression as well as higher SGK1 and P-SGK1 protein levels in the duodenal mucosa of children with untreated CD compared with controls. In the duodenal mucosa of children with treated CD, SGK1-mRNA expression was decreased and SGK1 and P-SGK1 protein levels were lower than in untreated CD. SGK1 and P-SGK1 staining intensity was stronger in duodenal villous enterocytes of children with untreated CD compared with treated CD. Conclusions: Our results of increased expression of SGK1 in untreated CD may suggest its contribution to the enterocyte survival in this disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk coeliac disease serum-and glucocorticoid-regulated kinase-1 children duodenal biopsies
Megjelenés:	Journal Of Pediatric Gastroenterology And Nutrition. - 50 : 2 (2010), p. 147-153. -
További szerzők:	Vannay Ádám Sziksz Erna Prokai Ágnes Cseh Áron Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Dezsőfi Antal Győrffy Hajnalka Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Arató András
Pályázati támogatás:	71730 OTKA T046082 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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