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001-es BibID:	BIBFORM096575
035-os BibID:	(cikkazonosító)8174 (scopus)85111357537 (wos)000681839700001
Első szerző:	Balla József (belgyógyász, nephrológus)
Cím:	Heme Burden and Ensuing Mechanisms That Protect the Kidney : insights from Bench and Bedside / Balla József, Zarjou Abolfazl
Dátum:	2021
ISSN:	1661-6596 1422-0067
Megjegyzések:	With iron at its core, the tetrapyrrole heme ring is a cardinal prosthetic group made up of many proteins that participate in a wide array of cellular functions and metabolism. Once released, due to its pro-oxidant properties, free heme in sufficient amounts can result in injurious effects to the kidney and other organs. Heme oxygenase-1 (HO-1) has evolved to promptly attend to such injurious potential by facilitating degradation of heme into equimolar amounts of carbon monoxide, iron, and biliverdin. HO-1 induction is a beneficial response to tissue injury in diverse animal models of diseases, including those that affect the kidney. These protective attributes are mainly due to: (i) prompt degradation of heme leading to restraining potential hazardous effects of free heme, and (ii) generation of byproducts that along with induction of ferritin have proven beneficial in a number of pathological conditions. This review will focus on describing clinical aspects of some of the conditions with the unifying end-result of increased heme burden and will discuss the molecular mechanisms that ensue to protect the kidneys.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Journal Of Molecular Sciences. - 22 : 15 (2021), p. 1-16. -
További szerzők:	Zarjou, Abolfazl (1979-) (kutató orvos)
Pályázati támogatás:	132828 OTKA GINOP-2.3.2-15-2016-00043 GINOP 11003 MTA ED_18-1-2019-0028 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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