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001-es BibID:	BIBFORM102226
Első szerző:	Hashmi, Amna (orvostanhallgató)
Cím:	Relevance of Proteinuria and Donor Specific Antibody in Kidney Transplanted Recipients and Allograft Outcomes / Amna Hashmi, Nóra Klenk, László Bidiga, László Kardos, Balázs Áron Nemes, József Balla, Réka P. Szabó
Dátum:	2022
ISSN:	0931-0509
Megjegyzések:	BACKGROUND AND AIMS The onset of proteinuria in renal allograft recipients is a frequent complication that may be associated with an increased risk of graft failure and mortality. Our aim was to research if proteinuria effects is independent from donor specific antibody (DSA) for transplant graft survival and the changes of proteinuria response to therapy in ABMR group. METHOD 85 transplanted patients were enrolled in our study and followed up till 31 October 2020 or till death, or date of return to dialysis. We created three groups: ABMR group (n = 19, biopsy proven antibody mediated rejection), ABMRDSApos positive group (n = 14) ABMRDSAneg (n = 5), DSA negative group with stabile kidney function without rejection as a reference (n = 52). Differences in patient, donor and transplant characteristics between DSA positive and negative groups were assessed by Fishers exact test for categorical variables. Death censored graft loss was assessed by Kaplan Meier analysis with log risk statistics. RESULTS Proteinuria decrease after treatment in ABMR group (P = 0.0009). Graft failure's frequency increase every 10 mg/mmol elevation of proteinuria means 7% elevation (hazard ratio: 1.07%). Before treatment nephrotic proteinuria was found in group AMBRDSApoz 21%, 14,29% in group ABMR DSAneg 1,92% in reference group. Estimated 3-year graft survival was 87, 5% in ABMR group, 93% in DSA pos group, and 100% in DSA negative group (log-rank probe P = 0.0666). CONCLUSION The presence of DSA increases graft loss but it is independent to proteinuria. Therapy refractory proteinuria state represents worse graft survival.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Nephrology Dialysis Transplantation. - 37 : 3 (2022), p. i689. -
További szerzők:	Klenk Nóra (1967-) (belgyógyász, nefrológus) Bidiga László (1977-) (patológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Nemes Balázs Áron (1969-) (sebész) Balla József (1959-) (belgyógyász, nephrológus) P. Szabó Réka (1979-) (orvos)
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